• Publications
  • Influence
Dendritic cells and the control of immunity
TLDR
Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis and the realization that these cells are a powerful tool for manipulating the immune system is realized.
Immunobiology of dendritic cells.
TLDR
Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
TLDR
Microarray analysis of blood cells reveals that immature granulocytes may be involved in SLE pathogenesis, and the IFN signature confirms the central role of this cytokine in Sle, using oligonucleotide microarrays.
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
TLDR
An important role is shown for neutrophils in lupus pathogenesis, whereby neutrophil activated by anti-self antibodies release NETs, which contain antimicrobial peptides complexed with self-DNA and activate plasmacytoid dendritic cells, leading to interferon release and furtherment and aggravation of inflammation and disease.
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
TLDR
Observations suggest that hIL-17 may constitute an early initiator of the T cell-dependent inflammmatory reaction; and an element of the cytokine network that bridges the immune system to hematopoiesis.
The Enigmatic Plasmacytoid T Cells Develop into Dendritic Cells with Interleukin (IL)-3 and CD40-Ligand
TLDR
It is demonstrated that CD4+ CD11c−CD3− cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues.
Cancer immunotherapy via dendritic cells
TLDR
Dendritic cells are an essential target in efforts to generate therapeutic immunity against cancer owing to their ability to control both immune tolerance and immunity.
Activation of human dendritic cells through CD40 cross-linking
TLDR
It is demonstrated that dendritic Langerhans cells (D-Lc) generated by culturing cord blood CD34+ progenitor cells with granulocyte/macrophage colony-stimulating and tumor necrosis factor alpha (TNF-alpha) express functional CD40 at a density higher than that found on B cells.
...
...