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Gene expression profiling predicts clinical outcome of breast cancer
TLDR
DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy. Expand
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
TLDR
These results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts, and seem to downregulate a far greater number of targets than previously appreciated. Expand
CTLA-4 is a second receptor for the B cell activation antigen B7
TLDR
These findings provide direct evidence that, like its structural homologue CD28, CTLA- 4 is able to bind the B7 counter-receptor on activated B cells. Expand
Genetics of gene expression surveyed in maize, mouse and man
Treating messenger RNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been pursued in gene-specific ways. Transcript abundancesExpand
Expression profiling reveals off-target gene regulation by RNAi
RNA interference is thought to require near-identity between the small interfering RNA (siRNA) and its cognate mRNA. Here, we used gene expression profiling to characterize the specificity of geneExpand
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
TLDR
This work argues that the cellular detection rate, the fraction of genes expressed in a cell, should be adjusted for as a source of nuisance variation and provides gene set enrichment analysis tailored to single-cell data. Expand
CTLA-4 can function as a negative regulator of T cell activation.
TLDR
Results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function. Expand
A microRNA component of the p53 tumour suppressor network
TLDR
A family of miRNAs, miR-34a–c, whose expression reflected p53 status is described, whose encoded genes are direct transcriptional targets of p53, whose induction by DNA damage and oncogenic stress depends on p53 both in vitro and in vivo. Expand
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors.
TLDR
It is shown that human CD86 maintains similar (within approximately 2- to 3-fold) overall receptor binding and T cell costimulatory properties as CD80, but CD80 and CD86 utilize different binding determinants and have different kinetics of binding to CD28 and CTLA-4. Expand
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Mice lacking miR-146a exhibit exaggerated inflammatory responses, autoimmunity, and increased rate of tumorigenesis.
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