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The mammalian target of rapamycin (mTOR) kinase is the catalytic subunit of two functionally distinct complexes, mTORC1 and… Expand The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby… Expand Adaptive immunity depends on T-cell exit from the thymus and T and B cells travelling between secondary lymphoid organs to survey… Expand Suppression of allograft rejection is central to successful organ transplantation; thus, immunosuppressive agents are crucial for… Expand BACKGROUND
Treatment with infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor, can result in the… Expand SUMMARY Endophytic microorganisms are to be found in virtually every plant on earth. These organisms reside in the living tissues… Expand Nutritional deprivation suppresses immune function. The cloning of the obese gene and identification of its protein product… Expand Apoptotic cell death is important in the development and homeostasis of multicellular organisms and is a highly controlled means… Expand Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their… Expand Cyclosporin A, FK506, and rapamycin are inhibitors of specific signal transduction pathways that lead to T lymphocyte activation… Expand