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Azaserine

Known as: L-Serine, diazoacetate (ester), L-Azaserine, AZAS 
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine… 
National Institutes of Health

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14 relations

Broader (5)

Antibiotics, AntineoplasticAntifungal AgentsAntimetabolites, AntineoplasticAzo Compounds
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Narrower (1)

P-165

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study.
Azaspiracids (AZAs) are marine phycotoxins with an unknown mechanism of action, implicated in human intoxications. We… 
Highly Cited
1987
Highly Cited
1987
High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.
Recent observations have suggested striking similarities between complement-mediated and cell-mediated lysis. Both pathways share… 
Highly Cited
1987
Highly Cited
1987
Effect of bombesin and caerulein on early stages of carcinogenesis induced by azaserine in the rat pancreas.
This study was designed to analyze the effect of two pancreaticotrophic peptides on pancreatic carcinogenesis in the azaserine… 
Highly Cited
1982
Highly Cited
1982
Promotion of liver carcinogenesis in the rat by a choline-devoid diet: role of liver cell necrosis and regeneration.
Promotion of liver carcinogenesis in the rat by a choline-devoid diet: role of liver cell necrosis and regeneration 
Highly Cited
1977
Highly Cited
1977
Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase…
Highly Cited
1973
Highly Cited
1973
Studies on possible routes of ammonium assimilation in soybean root nodule bacteroids.
  • S. DunnR. Klucas
  • Canadian Journal of Microbiology (print)
  • 1973
  • Corpus ID: 38369028
Glutamine amide–2-oxoglutarate aminotransferase NAD+ oxidoreductase (GOGAT), glutamine synthetase (GS), glutamate dehydrogenase… 
Highly Cited
1966
Highly Cited
1966
Le phénomène de la ségrégation nucléolaire: Spécificité d'action de certains antimétabolites
Sous l'effet de certains composés, le nucléole présente des lésions morphologiques distinctes et caractéristiques. Ces lésions… 
Highly Cited
1965
Highly Cited
1965
EFFECT OF AZASERINE ON THE FINE STRUCTURE OF THE LIVER AND PANCREATIC ACINAR CELLS.
Intraperitoneal administration of azaserine to adult rats resulted in characteristic alterations of rough endoplasmic reticulum… 
Highly Cited
1962
Highly Cited
1962
Autoradiographic studies of in vitro incorporation of uridine and thymidine by human tumor tissue.
Summary The incorporation of tritiated thymidine and uridine by slices of human tumors was studied in short-term tissue cultures… 
Highly Cited
1957
Highly Cited
1957
In vivo sensitivity of normal and neoplastic mouse tissues to azaserine.
Summary It was found that normal and neoplastic mouse tissues differed widely in their sensitivity to azaserine and 6-diazo-5-oxo… 
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