C. Moody

Publications760
h-index50
Citations11,784
Highly Influential Citations59
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Experimental Organic Chemistry: Principles and Practice
Part 1 Laboratory practice: safety in the chemical laboratory glassware and equipment in the laboratory organic reactions - from starting materials to pure organic product qualitative analysis of…
Experimental Organic Chemistry: Standard and Microscale
Preface. Part 1: Laboratory Practice. 1 Safety in the Chemical Laboratory. 2 Glasware and Equipment in the Laboratory. 3 Organic Reactions: from Starting Materials to Pure Organic Product. 4…
Oxidative activation of antioxidant defence.
Heat shock protein 90 controls HIV-1 reactivation from latency
TLDR
It is reported that specific inhibitors of Hsp90 such as 17-(N-allylamino)-17-demethoxygeldanamycin and AUY922 prevent HIV-1 reactivation in CD4+ T cells and, in combination with a PKC-ϑ inhibitor in phase II clinical trial, almost completely suppressed HIV- 1 reactivation at 15 nM with no cytotoxicity.
Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product.
TLDR
This review details the synthetic studies on this fascinating natural product starting from early studies on the original structure, through the synthesis of the originally proposed structure and the subsequent structural revision, to the eventual successful syntheses of the natural product itself.
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
TLDR
It is demonstrated that NQO1 inhibitory activity can be dissociated from growth inhibitoryActivity and suggested additional or alternative targets to NQo1 that are responsible for the growth inhibitor activity of this series of indolequinones in human pancreatic cancer.
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.
TLDR
A series of indolequinones are described as efficient mechanism-based inhibitors of NRH:quinone oxidoreductase 2 (NQO2) for use either in cellular or cell-free systems and represent the first mechanism- based inhibitors of NQO1 to be characterized in cellular systems.
Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones.
TLDR
Alpha-diazo-beta-ketosulfones behave similarly and give 5-sulfonyloxazoles upon dirhodium tetrakis(heptafluorobutyramide) catalyzed reaction with carboxamides, which gives the corresponding thiazole-5-carboxylates, -phosphonates, and -sulfones.
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