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- Publications
- Influence
Overlapping expression of Xwnt-3A and Xwnt-1 in neural tissue of Xenopus laevis embryos.
- S. L. Wolda, C. Moody, R. Moon
- Biology, Medicine
- Developmental biology
- 1993
Xwnt-3A is a member of the Xenopus-Wnt gene family, a class of secreted, cysteine-rich proteins implicated in intercellular signaling during early development. Here we describe the full-length coding… Expand
Oxidative activation of antioxidant defence.
- P. Winyard, C. Moody, C. Jacob
- Medicine, Chemistry
- Trends in biochemical sciences
- 1 August 2005
Living cells maintain a delicate balance between oxidizing and reducing species, and many disorders such as rheumatoid arthritis and Alzheimer's disease have been associated with a disturbed… Expand
Experimental Organic Chemistry: Standard and Microscale
- J. Percy, C. Moody, L. Harwood
- Chemistry
- 25 November 1998
Preface. Part 1: Laboratory Practice. 1 Safety in the Chemical Laboratory. 2 Glasware and Equipment in the Laboratory. 3 Organic Reactions: from Starting Materials to Pure Organic Product. 4… Expand
- 50
- 6
Experimental Organic Chemistry: Principles and Practice
- Laurence M. Harwood, C. Moody
- Chemistry
- 1990
Part 1 Laboratory practice: safety in the chemical laboratory glassware and equipment in the laboratory organic reactions - from starting materials to pure organic product qualitative analysis of… Expand
- 202
- 5
Heat shock protein 90 controls HIV-1 reactivation from latency
- I. Anderson, Jun Siong Low, +8 authors A. Fassati
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 March 2014
Significance Antiretroviral therapy cannot eradicate HIV-1 because the virus can become transcriptionally inactive in resting memory CD4+ T cells (and other cell types), which are long-lived, thus… Expand
Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived… Expand
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
- P. Reigan, Marie A. Colucci, D. Siegel, Aurélie Chilloux, C. Moody, D. Ross
- Chemistry, Medicine
- Biochemistry
- 25 April 2007
NAD(P)H:quinone oxidoreductase 1 (NQO1) is currently an emerging target in pancreatic cancer. In this report, we describe a series of indolequinones, based on… Expand
The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product.
- Mathilde Lachia, C. Moody
- Biology, Medicine
- Natural product reports
- 27 March 2008
The complex structure of the marine metabolic diazonamide A comprises a dichlorinated indole bis-oxazole heteroaromatic fragment, and a [b]-fused dihydrobenzofuran-dihydroindole unit containing an… Expand
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.
We describe a series of indolequinones as efficient mechanism-based inhibitors of NRH:quinone oxidoreductase 2 (NQO2) for use either in cellular or cell-free systems. Compounds were designed to be… Expand
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.
- D. Vigushin, G. Brooke, David Willows, R. C. Coombes, C. Moody
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 3 November 2003
Some pyrazino[1,2-a]indole-1,4-diones, structurally simplified analogues of the natural mycotoxin gliotoxin, have been synthesised and investigated as inhibitors of prenyltransferases; one compound,… Expand