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Complement Inactivating Agents

Known as: Complement Inhibitors, complement inhibitor, Inhibiting Agents, Complement 
Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is… 
National Institutes of Health

Related topics

Related topics

22 relations

Narrower (13)

C1 esterase inhibitorC4bp complement proteinC5a peptidaseCD59 Antigen
Complement ActivationComplement Inhibitor [EPC]Immunosuppressive AgentsIn Blood

Broader (1)

antagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Species specificity of the complement inhibitor compstatin investigated by all‐atom molecular dynamics simulations
The development of compounds to regulate the activation of the complement system in non‐primate species is of profound interest… 
2009
2009
Characterization of the Complement Inhibitory Function of Rhesus Rhadinovirus Complement Control Protein (RCP)*
Rhesus rhadinovirus (RRV) is currently the closest known, fully sequenced homolog of human Kaposi sarcoma-associated herpesvirus… 
2004
2004
Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology.
Recombinant soluble human complement receptor type 1 (sCR1) is a highly glycosylated glycoprotein intended for use as a drug to… 
Highly Cited
2003
Highly Cited
2003
Association Between Complement Factor H and Proteoglycans in Early Human Coronary Atherosclerotic Lesions: Implications for Local Regulation of Complement Activation
Objective—Complement activation has been suggested to play a role in atherogenesis. To study the regulation of complement… 
2003
2003
Prevention of Collagen-Induced Arthritis in Mice Transgenic for the Complement Inhibitor Complement Receptor 1-Related Gene/Protein y1
The objective of these studies was to examine collagen-induced arthritis (CIA) in C57BL/6 mice transgenic for the rodent… 
1996
1996
Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59.
CD59 antigen is a membrane glycoprotein that inhibits the activity of the C9 component of the C5b-9 membrane attack complex (MAC… 
Highly Cited
1995
Highly Cited
1995
Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent
CD59, an 18-20-kD complement inhibitor anchored to the membrane via glycosyl phosphatidylinositol (GPI), can induce activation of… 
Highly Cited
1994
Highly Cited
1994
Inhibition of complement-mediated cytolysis by the terminal complement inhibitor of herpesvirus saimiri
Herpesvirus saimiri (HVS) is a lymphotropic herpesvirus that induces T-cell transformation in vitro and causes lymphomas and… 
1993
1993
HIV‐I and HIV‐2 isolates differ in their ability to activate the complement system on the surface of infected cells
OBJECTIVE To analyse the ability of different HIV-1 and HIV-2 isolates to activate the complement system. DESIGN H9 cells… 
Highly Cited
1993
Highly Cited
1993
Expression of messenger RNAs for complement inhibitors in human tissues and tumors.
The mRNAs coding for three complement inhibitors produced by human cells, complement cytolysis inhibitor (CLI), decay… 
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