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Complement Inactivating Agents
Known as:
Complement Inhibitors
, complement inhibitor
, Inhibiting Agents, Complement
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Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is…
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National Institutes of Health
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Related topics
Related topics
22 relations
Narrower (13)
C1 esterase inhibitor
C4bp complement protein
C5a peptidase
CD59 Antigen
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Complement Activation
Complement Inhibitor [EPC]
Immunosuppressive Agents
In Blood
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Broader (1)
antagonists & inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Species specificity of the complement inhibitor compstatin investigated by all‐atom molecular dynamics simulations
P. Tamamis
,
D. Morikis
,
C. Floudas
,
G. Archontis
Proteins: Structure, Function, and Bioinformatics
2010
Corpus ID: 16360793
The development of compounds to regulate the activation of the complement system in non‐primate species is of profound interest…
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Highly Cited
2004
Highly Cited
2004
The Group B Streptococcal β and Pneumococcal Hic Proteins Are Structurally Related Immune Evasion Molecules That Bind the Complement Inhibitor Factor H in an Analogous Fashion 1
H. Jarva
,
J. Hellwage
,
T. Jokiranta
,
M. Lehtinen
,
P. Zipfel
,
S. Meri
Journal of Immunology
2004
Corpus ID: 44388258
Complement evasion by different mechanisms is important for microbial virulence and survival in the host. One strategy used by…
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Review
2004
Review
2004
Functions of human complement inhibitor C4b-binding protein in relation to its structure.
A. Blom
,
B. Villoutreix
,
B. Dahlbäck
Archivum Immunologiae et Therapiae Experimentalis
2004
Corpus ID: 27804573
Considering the destructive potential of the complement cascade, it is no surprise that there are several complement inhibitors…
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Highly Cited
2003
Highly Cited
2003
Association Between Complement Factor H and Proteoglycans in Early Human Coronary Atherosclerotic Lesions: Implications for Local Regulation of Complement Activation
R. Oksjoki
,
H. Jarva
,
P. Kovanen
,
Petri Laine
,
S. Meri
,
M. Pentikäinen
Arteriosclerosis, Thrombosis and Vascular Biology
2003
Corpus ID: 28947094
Objective—Complement activation has been suggested to play a role in atherogenesis. To study the regulation of complement…
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Highly Cited
2002
Highly Cited
2002
Transgenic Expression of a Soluble Complement Inhibitor Protects Against Renal Disease and Promotes Survival in MRL/lpr Mice1
L. Bao
,
M. Haas
,
+8 authors
R. Quigg
Journal of Immunology
2002
Corpus ID: 39791773
To investigate the role of complement in lupus nephritis, we used MRL/lpr mice and a transgene overexpressing a soluble…
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1999
1999
Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 (MCP), CD55 (DAF) and CD59 in gastrointestinal tumours.
C. Schmitt
,
W. Schwaeble
,
B. Wittig
,
K. Meyer zum Büschenfelde
,
W. Dippold
European Journal of Cancer
1999
Corpus ID: 28181163
Highly Cited
1995
Highly Cited
1995
Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent
Carmen W Van Den Berg
,
T. Cinek
,
M. B. Hallett
,
Vaclav Horejsi
,
B. Morgan
,
P. Morgan
Journal of Cell Biology
1995
Corpus ID: 15284443
CD59, an 18-20-kD complement inhibitor anchored to the membrane via glycosyl phosphatidylinositol (GPI), can induce activation of…
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Highly Cited
1994
Highly Cited
1994
Inhibition of complement-mediated cytolysis by the terminal complement inhibitor of herpesvirus saimiri
R. Rother
,
Scott A. Rollins
,
+4 authors
S. Squinto
Journal of Virology
1994
Corpus ID: 22943069
Herpesvirus saimiri (HVS) is a lymphotropic herpesvirus that induces T-cell transformation in vitro and causes lymphomas and…
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1993
1993
HIV‐I and HIV‐2 isolates differ in their ability to activate the complement system on the surface of infected cells
P. Marschang
,
L. Gurtler
,
+5 authors
M. Dierich
AIDS (London)
1993
Corpus ID: 42132483
OBJECTIVE To analyse the ability of different HIV-1 and HIV-2 isolates to activate the complement system. DESIGN H9 cells…
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Highly Cited
1993
Highly Cited
1993
Expression of messenger RNAs for complement inhibitors in human tissues and tumors.
Sanjay Kumar
,
J. M. Vinci
,
B. Pytel
,
C. Baglioni
Cancer Research
1993
Corpus ID: 25860771
The mRNAs coding for three complement inhibitors produced by human cells, complement cytolysis inhibitor (CLI), decay…
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