Complement Inactivating Agents

Known as: Complement Inhibitors, complement inhibitor, Inhibiting Agents, Complement 
Compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is… (More)
National Institutes of Health

Related topics

Related topics

22 relations

Narrower (13)

C1 esterase inhibitorC4bp complement proteinC5a peptidaseCD59 Antigen
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Complement ActivationComplement Inhibitor [EPC]Immunosuppressive AgentsIn Blood
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Broader (1)

antagonists & inhibitors

Papers overview

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Highly Cited
2011
Highly Cited
2011
A meningococcal factor H binding protein mutant that eliminates factor H binding enhances protective antibody responses to vaccination.
Certain pathogens recruit host complement inhibitors such as factor H (fH) to evade the immune system. Microbial complement… (More)
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Highly Cited
2008
Highly Cited
2008
Differences in global gene expression in peripheral blood mononuclear cells indicate a significant role of the innate responses in progression of dengue fever but not dengue hemorrhagic fever.
BACKGROUND Dengue virus infection causes an array of symptoms ranging from dengue fever (DF) to dengue hemorrhagic fever (DHF… (More)
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Highly Cited
2007
Highly Cited
2007
Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation… (More)
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Highly Cited
2006
Highly Cited
2006
The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages.
Two newly discovered immune modulators, chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) and staphylococcal… (More)
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Highly Cited
2006
Highly Cited
2006
Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.
Ischemia/reperfusion (I/R) of several organs results in complement activation, but the kidney is unique in that activation after… (More)
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Highly Cited
2005
Highly Cited
2005
Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases
The complement system is pivotal in host defense but also contributes to tissue injury in several diseases. The assembly of C3… (More)
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Highly Cited
2002
Highly Cited
2002
Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes.
The Lyme disease spirochete, Borrelia burgdorferi, is capable of infecting a wide variety of vertebrates. This broad host range… (More)
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Highly Cited
2001
Highly Cited
2001
Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma.
Rituximab is a chimeric monoclonal antibody that targets B-cell-specific antigen CD20 and an effective treatment for B-cell non… (More)
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Highly Cited
1994
Highly Cited
1994
Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection.
The serious shortage of human organs available for transplantation has engendered a heightened interest in the use of animal… (More)
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Highly Cited
1993
Highly Cited
1993
Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem-cell disorder in which the glycolipid-anchored membrane proteins… (More)
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