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Integrins and signal transduction pathways: the road taken.
TLDR
Recent advances in understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors are focused on. Expand
Genomic analysis of metastasis reveals an essential role for RhoC
TLDR
An in vivo selection scheme is used to select highly metastatic melanoma cells to identify families of genes involved in a process, not just single genes, and can indicate which molecular and cellular events might be important in complex biological processes such as metastasis. Expand
Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases
TLDR
Several separable signaling pathways regulated by different members of the Rho family of GTPases converge to control adhesion-dependent changes in the organization of the cytoskeleton, changes that regulate cell morphology and behavior. Expand
Molecular and biological characterization of a murine ligand for CD40
TLDR
The cloning of a ligand for CD40 that is expressed on the cell surface of activated T cells and mediates B-cell proliferation in the absence of co-stimulus, as well as IgE production in the presence of interIeukin-4 is reported. Expand
Decision making in the immune system: Regulation of B-cell fate by antigen-receptor signals
TLDR
Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development, which indicates that key kinases and adaptors fine-tune BCR signalling to direct appropriate cell fates. Expand
BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway
TLDR
It is suggested that mature B cell homeostasis is maintained by BAFF-mediated regulation of Bim, demonstrating that BAFF directly regulates Bim function. Expand
The dual-function CD150 receptor subfamily: the viral attraction
TLDR
The CD150 subfamily within the CD2 family is a growing group of dual-function receptors that have within their cytoplasmic tails a characteristic signaling motif that leads to the activation of interferon-γ, a key cytokine for viral immunity. Expand
T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.
TLDR
It is shown that the CD28 antigen, expressed in Chinese hamster ovary cells, mediated specific intercellular adhesion with human lymphoblastoid and leukemic B-cell lines and with activated primary murine B cells, and represents a heterophilic interaction between members of the immunoglobulin superfamily that may serve to regulate T-cell cytokine levels at sites of B- cell activation. Expand
Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1
TLDR
It is shown that Mst1 is specifically cleaved by a caspase 3‐like activity during apoptosis induced by either cross‐linking CD95/Fas or by staurosporine treatment, and the existence of a positive feedback loop involving Mst2, and possibly the SAPK and p38 MAPK pathways, which serves to amplify the apoptotic response. Expand
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.
TLDR
An optimal kinase activity of SyK and an interaction between the linker region of Syk with PLC-gamma1 are required for the tyrosyl phosphorylation of PL-Gamma1. Expand
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