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Vorinostat

Known as: Octanedioic acid hydroxyamide phenylamide, SAHA, N-Hydroxy-N'-phenyl octanediamide 
A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (3)

18F-SAHAM344Zolinza
Angiogenesis InhibitionHistone DeacetylaseNCIt Antineoplastic Agent TerminologyPositive Regulation of Apoptosis

Broader (3)

Antineoplastic AgentsHistone deacetylase inhibitorHydroxamic Acids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsis.
Much of the morbidity and mortality of sickle cell anemia is accounted for by a chronic vasculopathy syndrome. There is currently… 
Highly Cited
2007
Highly Cited
2007
Epigenetic combination therapy as a tumor‐selective treatment approach for hepatocellular carcinoma
Innovative epigenetic therapeutics comprise histone deacetylase inhibitors (HDAC‐I) and demethylating agents (DA). It was… 
Highly Cited
2007
Highly Cited
2007
HDAC inhibitors overcome first hurdle
Despite US marketing approval for the first histone deacetylase inhibitor, these prolific agents still have a lot to prove. 
Highly Cited
2006
Highly Cited
2006
Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies.
Highly Cited
2006
Highly Cited
2006
Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation.
Recently, the inhibition of histone deacetylase (HDAC) enzymes has attracted attention in the oncologic community as a new… 
Highly Cited
2005
Highly Cited
2005
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and…
Interactions between histone deacetylase inhibitors (HDACIs) and the alkyl-lysophospholipid perifosine were examined in human… 
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Highly Cited
2001
Highly Cited
2001
Diagnostics of silicon plasmas produced by visible nanosecond laser ablation
Highly Cited
2000
Highly Cited
2000
Securing electronic commerce: reducing the SSL overhead
The last couple of years have seen a growing momentum toward using the Internet for conducting business. Web-based electronic… 
Highly Cited
1993
Highly Cited
1993
Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver.
An increase of the hepatocellular hydratation state, induced by hypotonic exposure, amino acids or tauroursodeoxycholate, was… 
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