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Vorinostat

Known as: Octanedioic acid hydroxyamide phenylamide, SAHA, N-Hydroxy-N'-phenyl octanediamide 
A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to… Expand
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Highly Cited
2009
Highly Cited
2009
Lysine Acetylation Catalog Covalent posttranslational modification is an essential cellular regulatory mechanism by which the… Expand
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Highly Cited
2009
Highly Cited
2009
Boron- and nitrogen-doped graphenes are are prepared by the arc discharge between carbon electrodes or by the transformation of… Expand
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Review
2007
Review
2007
In our quest to understand why dimethyl sulfoxide (DMSO) can cause growth arrest and terminal differentiation of transformed… Expand
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Highly Cited
2007
Highly Cited
2007
On October 6, 2006, the U.S. Food and Drug Administration granted regular approval to vorinostat (Zolinza(R); Merck & Co., Inc… Expand
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Highly Cited
2007
Highly Cited
2007
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… Expand
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Highly Cited
2007
Highly Cited
2007
  • E. Olsen, Y. Kim, +8 authors M. Duvic
  • Journal of clinical oncology : official journal…
  • 2007
  • Corpus ID: 19558322
PURPOSE To evaluate the activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in… Expand
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Review
2000
Review
2000
Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth arrest, differentiation, and/or apoptotic… Expand
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Highly Cited
2000
Highly Cited
2000
Histone deacetylases (HDACs) catalyze the removal of acetyl groups on the amino-terminal lysine residues of core nucleosomal… Expand
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Highly Cited
1999
Highly Cited
1999
Histone deacetylases (HDACs) mediate changes in nucleosome conformation and are important in the regulation of gene expression… Expand
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