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Vorinostat

Known as: Octanedioic acid hydroxyamide phenylamide, SAHA, N-Hydroxy-N'-phenyl octanediamide 
A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (3)

18F-SAHAM344Zolinza
Angiogenesis InhibitionHistone DeacetylaseNCIt Antineoplastic Agent TerminologyPositive Regulation of Apoptosis

Broader (3)

Antineoplastic AgentsHistone deacetylase inhibitorHydroxamic Acids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).
Histone deacetylases (HDACs) are a group of enzymes that modulate gene expression and cell state by deacetylation of both histone… 
Highly Cited
2010
Highly Cited
2010
Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex.
Review
2010
Review
2010
Strategies in developing promising histone deacetylase inhibitors
Histone deacetylases (HDACs) are a family of enzymes that have been of interest in drug discovery for more than 30 years… 
Highly Cited
2009
Highly Cited
2009
Activation and Inhibition of Histone Deacetylase 8 by Monovalent Cations*
The metal-dependent histone deacetylases (HDACs) catalyze hydrolysis of acetyl groups from acetyllysine side chains and are… 
Highly Cited
2005
Highly Cited
2005
A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.
We have developed a procedure for the synthesis of N-hydroxy-N(1)-phenyloctanediamide (suberoylanilide hydroxamic acid (SAHA… 
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Highly Cited
2002
Highly Cited
2002
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P‐glycoprotein‐expressing cells
Multidrug resistance (MDR) mediated by the ATP‐dependent efflux protein P‐glycoprotein (P‐gp) is a major obstacle to the… 
Highly Cited
2002
Highly Cited
2002
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors.
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been shown to inhibit the development of N… 
Highly Cited
2000
Highly Cited
2000
Securing electronic commerce: reducing the SSL overhead
The last couple of years have seen a growing momentum toward using the Internet for conducting business. Web-based electronic… 
Highly Cited
1962
Highly Cited
1962
Evidence for the complete DNA-dependence of RNA synthesis in isolated thymus nuclei.
31 Brown, W. 0., and H. (G. Badman, Biochem. J., 78, 571 (1961). 14 Hunter, F. T., The Quantitation of Mixtures of Hemoglobin… 
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