Vorinostat

Known as: Octanedioic acid hydroxyamide phenylamide, SAHA, N-Hydroxy-N'-phenyl octanediamide 
A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
UNLABELLED Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+ T-cells is the major barrier… (More)
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Highly Cited
2012
Highly Cited
2012
Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to… (More)
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Highly Cited
2010
Highly Cited
2010
Autophagy is an evolutionarily conserved cell survival pathway that enables cells to recoup ATP and other critical biosynthetic… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by both histone and nonhistone-mediated mechanisms… (More)
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Highly Cited
2007
Highly Cited
2007
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… (More)
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Review
2007
Review
2007
In our quest to understand why dimethyl sulfoxide (DMSO) can cause growth arrest and terminal differentiation of transformed… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To evaluate the activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in… (More)
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Highly Cited
2007
Highly Cited
2007
On October 6, 2006, the U.S. Food and Drug Administration granted regular approval to vorinostat (Zolinza(R); Merck & Co., Inc… (More)
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Highly Cited
2007
Highly Cited
2007
Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor active clinically in cutaneous T-cell… (More)
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Review
2007
Review
2007
Epigenetic regulation of gene transcription by small-molecule inhibitors of histone deacetylases (HDACs) is a novel cancer… (More)
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