Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather than AKT inhibition

@article{Rahmani2003InhibitionOP,
  title={Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather than AKT inhibition},
  author={Mohamed Rahmani and Chunrong Yu and Erin L Reese and Wesam Ahmed and Karen Hirsch and Paul Dent and Steven Grant},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6231-6242}
}
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone deacetylase inhibitors (HDIs). Coexposure of U937 cells for 24 h to marginally toxic concentrations of LY294002 (e.g., 30 μM) and sodium butyrate (SB; 1 mM) resulted in a marked increase in mitochondrial damage (e.g., cytochrome c and Smac/DIABLO release, loss of ΔΨm), caspase activation, and apoptosis. Similar results were observed in Jurkat, HL-60, and K562… CONTINUE READING
46 Citations
12 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

Curr

  • DR Alessi, P. Cohen
  • Opin. Genet. Dev., 8, 55–62.
  • 1998
Highly Influential
2 Excerpts

Br

  • D Lewandowski, C Linassier, +5 authors O. Herault
  • J. Haematol., 118, 535–544.
  • 2002
2 Excerpts

Clin

  • Wang, Li, Kim, Evers.
  • Cancer Res., 8, 1940–1947.
  • 2002

J

  • B Yusta, J Estall, DJ. Drucker
  • Biol. Chem., 277, 24896–24906.
  • 2002

Drug Resist

  • M Fan, Chambers TC.
  • Updat., 4, 253–267.
  • 2001

Endocr

  • Stein RC.
  • Relat. Cancer, 8, 237–248.
  • 2001

Int

  • S. Grant
  • J. Oncol, 19, 181–191. Rossig L, Badorff C…
  • 2001

Nat

  • P Marks, RA Rifkind, VM Richon, R Breslow, T Miller, WK. Kelly
  • Rev. Cancer., 1, 194–202.
  • 2001
1 Excerpt

Proc

  • JR Testa, A. Bellacosa
  • Natl. Acad. Sci. USA, 98, 10983–10985.
  • 2001

Anticancer Res., 20

  • 2000

Similar Papers

Loading similar papers…