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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is the signature event in pancreatic ductalExpand
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Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
Monitoring Monocyte Reservoirs Monocytes are cells of the immune system that are recruited to sites of tissue injury and inflammation where they help to resolve the infection and are important forExpand
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Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation
Dynamic measurements of regional changes in cerebral blood volume (CBV) were performed in rat models of hypercarbia and focal neuronal activation using T2‐weighted imaging after injection of anExpand
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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Healing of myocardial infarction (MI) requires monocytes/macrophages. These mononuclear phagocytes likely degrade released macromolecules and aid in scavenging of dead cardiomyocytes, while mediatingExpand
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Epigenetic memory in induced pluripotent stem cells
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through differentExpand
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Restoration of p53 function leads to tumour regression in vivo
Tumorigenesis is a multi-step process that requires activation of oncogenes and inactivation of tumour suppressor genes. Mouse models of human cancers have recently demonstrated that continuousExpand
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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf et al. 2007. J. Exp. Med. doi:10.1084/jem.20070885 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumbExpand
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Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
BACKGROUND Accurate detection of lymph-node metastases in prostate cancer is an essential component of the approach to treatment. We investigated whether highly lymphotropic superparamagneticExpand
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The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here,Expand
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