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Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation
TLDR
Dynamic measurements of regional changes in cerebral blood volume (CBV) were performed in rat models of hypercarbia and focal neuronal activation using T2‐weighted imaging after injection of an intravascular contrast agent with a very long blood half‐life to suggest proportional changes in blood volume for capillaries and small veins.
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
TLDR
It is shown that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation and identifies splenic monocytes as a resource that the body exploits to regulate inflammation.
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
TLDR
This work identifies two distinct phases of monocyte participation after MI and proposes a model that reconciles the divergent properties of these cells in healing and identifies new therapeutic targets that can influence healing and ventricular remodeling after MI.
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
TLDR
In vivo mechanistic insights are provided into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC.
Epigenetic memory in induced pluripotent stem cells
TLDR
It is observed that low-passage induced pluripotent stem cells (iPSCs) derived by factor-based reprogramming of adult murine tissues harbour residual DNA methylation signatures characteristic of their somatic tissue of origin, which favours their differentiation along lineages related to the donor cell, while restricting alternative cell fates.
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
TLDR
It is demonstrated that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes, and appears to function as a corepressor of the transcription factor Hif1alpha, a critical regulator of nutrient stress responses.
Restoration of p53 function leads to tumour regression in vivo
TLDR
It is shown that restoring endogenous p53 expression leads to regression of autochthonous lymphomas and sarcomas in mice without affecting normal tissues, and support efforts to treat human cancers by way of pharmacological reactivation of p53.
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
TLDR
High-resolution MRI with magnetic nanoparticles allows the detection of small and otherwise undetectable lymph-node metastases in patients with prostate cancer.
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Nahrendorf et al. 2007. J. Exp. Med. doi:10.1084/jem.20070885 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
TLDR
SIRT6 is identified as a tumor suppressor that regulates aerobic glycolysis in cancer cells and functions as a regulator of ribosome metabolism by corepressing MYC transcriptional activity, highlighting SIRT6 as a critical modulator of cancer metabolism.
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