Histone deacetylase inhibitor

Known as: HDAC Agent, HDAC inhibitor, HDAC Inhibitors 
Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone… (More)
National Institutes of Health

Papers overview

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Review
2014
Review
2014
Epigenetic enzymes are often dysregulated in human tumors through mutation, altered expression, or inappropriate recruitment to… (More)
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Review
2009
Review
2009
The role of histone deacetylases (HDAC) and the potential of these enzymes as therapeutic targets for cancer, neurodegenerative… (More)
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Highly Cited
2006
Highly Cited
2006
Improved understanding of the molecular mechanisms by which small-molecule inhibitors of histone deacetylases (HDAC) induce… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Angiogenesis is required for tumor progression and represents a rational target for therapeutic intervention. Histone… (More)
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Highly Cited
2005
Highly Cited
2005
This study examines the basis of resistance and sensitivity of normal and transformed cells to histone deacetylase inhibitor… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The objective of this study was to define the maximum-tolerated dose (MTD), the recommended phase II dose, the dose… (More)
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Highly Cited
2005
Highly Cited
2005
Despite advances in understanding the role of histone deacetylases (HDACs) in tumorigenesis, the mechanism by which HDAC… (More)
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Highly Cited
2004
Highly Cited
2004
Histone deacetylase (HDAC) inhibitors can induce programmed cell death in cancer cells, although the underlying mechanism is… (More)
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Highly Cited
2003
Highly Cited
2003
Studies in human systemic lupus erythematosus (SLE) suggest a possible role for histone deacetylases (HDACs) in skewed gene… (More)
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Highly Cited
2001
Highly Cited
2001
Histone acetylation has long been associated with transcriptional activation, whereas conversely, deacetylation of histones is… (More)
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