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Histone deacetylase inhibitor

Known as: HDAC Agent, HDAC inhibitor, HDAC Inhibitors 
Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone… 
National Institutes of Health

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Histone Deacetylase Inhibitor [EPC]In Bloodaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Class II‐specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL‐8 expression in human melanoma cells
Here, we explored the effects of the novel class II‐specific histone deacetylase inhibitors (HDACis) MC1568 and MC1575 on… 
Highly Cited
2011
Highly Cited
2011
In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).
Histone deacetylases (HDACs) are a group of enzymes that modulate gene expression and cell state by deacetylation of both histone… 
Highly Cited
2011
Highly Cited
2011
A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignant neoplasm and more than 50% of patients… 
Review
2010
Review
2010
Strategies in developing promising histone deacetylase inhibitors
Histone deacetylases (HDACs) are a family of enzymes that have been of interest in drug discovery for more than 30 years… 
Highly Cited
2008
Highly Cited
2008
A novel effect of DNA methyltransferase and histone deacetylase inhibitors : NFκB inhibition in malignant myeloblasts
Malignant myeloblasts arising in high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are characterized by… 
2007
2007
Bispyridinium dienes: histone deacetylase inhibitors with selective activities.
A novel synthetic route to the cyclostellettamines 1 using as the key step a microwave-mediated macrocyclic ring-closing… 
2006
2006
RETRACTION: Flavopiridol and Histone Deacetylase Inhibitors Promote Mitochondrial Injury and Cell Death in Human Leukemia Cells That Overexpress Bcl-2
Interactions between the cyclin-dependent kinase (CDK) inhibitor flavopiridol and histone deacetylase (HDAC) inhibitors… 
Highly Cited
2004
Highly Cited
2004
Synergistic Effect of Histone Deacetylase Inhibitors FK228 and m-Carboxycinnamic Acid Bis-Hydroxamide with Proteasome Inhibitors PSI and PS-341 against Gastrointestinal Adenocarcinoma Cells
Purpose: We investigated whether the histone deacetylase inhibitors m-carboxycinnamic acid bis-hydroxamide (CBHA) and a bicyclic… 
Highly Cited
2004
Highly Cited
2004
Contribution of Disruption of the Nuclear Factor-κB Pathway to Induction of Apoptosis in Human Leukemia Cells by Histone Deacetylase Inhibitors and Flavopiridol
Interactions between the cyclin-dependent kinase inhibitor flavopiridol and the histone deacetylase inhibitors (HDACIs) sodium… 
Highly Cited
2000
Highly Cited
2000
Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
Apicidin's indole was efficiently converted into a series of N-substituted quinolone derivatives by indole N-alkylation followed… 
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