Hydroxamic Acids

Known as: Hydroxamic Acids [Chemical/Ingredient], Hydroxamic Acid, Acid, Hydroxamic 
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently… (More)
National Institutes of Health

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2,6-pyridinedicarbohydroxamic acid2-nitroimidazole-1-acetohydroxamic acid3,4,5-trihydroxybenzohydroxamic acidABT-770
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In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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Highly Cited
2009
Highly Cited
2009
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression… (More)
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Highly Cited
2007
Highly Cited
2007
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… (More)
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Highly Cited
2005
Highly Cited
2005
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.
PURPOSE To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone… (More)
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Highly Cited
2003
Highly Cited
2003
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat… (More)
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Highly Cited
2003
Highly Cited
2003
Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.
PURPOSE To evaluate the safety, pharmacokinetics, and biological activity of suberoylanilide hydroxamic acid (SAHA) administered… (More)
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Highly Cited
2002
Highly Cited
2002
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and… (More)
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Highly Cited
2001
Highly Cited
2001
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen…
Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate apoptosis. However, the upstream events leading… (More)
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Highly Cited
2000
Highly Cited
2000
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in… (More)
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Highly Cited
1971
Highly Cited
1971
Specific inhibition of the cyanide-insensitive respiratory pathway in plant mitochondria by hydroxamic acids.
Hydroxamic acids, R-CONHOH, are inhibitors specific to the respiratory pathway through the alternate, cyanide-insensitive… (More)
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Highly Cited
1961
Highly Cited
1961
A new and rapid colorimetric determination of acetylcholinesterase activity.
A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has… (More)
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