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Hydroxamic Acids

Known as: Hydroxamic Acids [Chemical/Ingredient], Hydroxamic Acid, Acid, Hydroxamic 
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Abstract Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site… Expand
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Highly Cited
2009
Highly Cited
2009
Lysine Acetylation Catalog Covalent posttranslational modification is an essential cellular regulatory mechanism by which the… Expand
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Highly Cited
2007
Highly Cited
2007
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone… Expand
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Highly Cited
2004
Highly Cited
2004
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress… Expand
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Highly Cited
2003
Highly Cited
2003
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE To evaluate the safety, pharmacokinetics, and biological activity of suberoylanilide hydroxamic acid (SAHA) administered… Expand
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Highly Cited
2000
Highly Cited
2000
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in… Expand
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Highly Cited
1988
Highly Cited
1988
Abstract Hydroxamic acids of the type 4-hydroxy-1,4-benzoxazin-3-ones constitute one of the most extensively studied secondary… Expand
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Highly Cited
1961
Highly Cited
1961
Abstract A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions… Expand
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