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Hydroxamic Acids

Known as: Hydroxamic Acids [Chemical/Ingredient], Hydroxamic Acid, Acid, Hydroxamic 
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently… Expand
National Institutes of Health

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2,6-pyridinedicarbohydroxamic acid2-nitroimidazole-1-acetohydroxamic acid3,4,5-trihydroxybenzohydroxamic acidABT-770
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In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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Review
2018
Review
2018
Zinc binding groups for histone deacetylase inhibitors
Abstract Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site… Expand
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Highly Cited
2009
Highly Cited
2009
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Lysine Acetylation Catalog Covalent posttranslational modification is an essential cellular regulatory mechanism by which the… Expand
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Highly Cited
2007
Highly Cited
2007
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… Expand
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Highly Cited
2005
Highly Cited
2005
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.
PURPOSE To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone… Expand
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Highly Cited
2004
Highly Cited
2004
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress… Expand
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Highly Cited
2003
Highly Cited
2003
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat… Expand
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Highly Cited
2003
Highly Cited
2003
Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.
PURPOSE To evaluate the safety, pharmacokinetics, and biological activity of suberoylanilide hydroxamic acid (SAHA) administered… Expand
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Highly Cited
2000
Highly Cited
2000
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in… Expand
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Highly Cited
1988
Highly Cited
1988
Hydroxamic acids (4-hydroxy-1,4-benzoxazin-3-ones), defence chemicals in the Gramineae
Abstract Hydroxamic acids of the type 4-hydroxy-1,4-benzoxazin-3-ones constitute one of the most extensively studied secondary… Expand
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Highly Cited
1961
Highly Cited
1961
A new and rapid colorimetric determination of acetylcholinesterase activity.
Abstract A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions… Expand
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