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Hydroxamic Acids
Known as:
Hydroxamic Acids [Chemical/Ingredient]
, Hydroxamic Acid
, Acid, Hydroxamic
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A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently…
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National Institutes of Health
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Related topics
Related topics
50 relations
Narrower (46)
2,6-pyridinedicarbohydroxamic acid
2-nitroimidazole-1-acetohydroxamic acid
3,4,5-trihydroxybenzohydroxamic acid
ABT-770
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In Blood
agonists
antagonists & inhibitors
chemical synthesis
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary
,
Chanchal Kumar
,
+5 authors
M. Mann
Science
2009
Corpus ID: 206520776
Lysine Acetylation Catalog Covalent posttranslational modification is an essential cellular regulatory mechanism by which the…
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Highly Cited
2007
Highly Cited
2007
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
M. Duvic
,
Rakshandra Talpur
,
+8 authors
S. Frankel
Blood
2007
Corpus ID: 9406471
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in…
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Highly Cited
2005
Highly Cited
2005
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.
W. Kelly
,
O. O’Connor
,
+13 authors
V. Richon
Journal of Clinical Oncology
2005
Corpus ID: 45562532
PURPOSE To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone…
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Highly Cited
2004
Highly Cited
2004
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
A. Vannini
,
C. Volpari
,
+9 authors
S. Di Marco
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 29619304
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress…
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Highly Cited
2003
Highly Cited
2003
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
E. Hockly
,
V. Richon
,
+13 authors
G. Bates
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 20766164
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat…
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Highly Cited
2002
Highly Cited
2002
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
F. Leoni
,
A. Zaliani
,
+16 authors
P. Mascagni
Proceedings of the National Academy of Sciences…
2002
Corpus ID: 24395928
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and…
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Highly Cited
2000
Highly Cited
2000
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.
L. Butler
,
D. Agus
,
+7 authors
V. Richon
Cancer Research
2000
Corpus ID: 3075764
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in…
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Highly Cited
1997
Highly Cited
1997
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
R. Black
,
C. Rauch
,
+17 authors
Douglas Pat Cerretti
Nature
1997
Corpus ID: 4251053
Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins1. Modification of the cell…
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Highly Cited
1961
Highly Cited
1961
A new and rapid colorimetric determination of acetylcholinesterase activity.
G. Ellman
,
K. Courtney
,
V. Andrés
,
R. M. Featherstone
Biochemical Pharmacology
1961
Corpus ID: 11072006
Highly Cited
1949
Highly Cited
1949
The reaction of acetylcholine and other carboxylic acid derivatives with hydroxylamine, and its analytical application.
S. Hestrin
Journal of Biological Chemistry
1949
Corpus ID: 38250121
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