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Hydroxamic Acids

Known as: Hydroxamic Acids [Chemical/Ingredient], Hydroxamic Acid, Acid, Hydroxamic 
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently… 
National Institutes of Health

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2,6-pyridinedicarbohydroxamic acid2-nitroimidazole-1-acetohydroxamic acid3,4,5-trihydroxybenzohydroxamic acidABT-770
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In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

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Highly Cited
2009
Highly Cited
2009
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Lysine Acetylation Catalog Covalent posttranslational modification is an essential cellular regulatory mechanism by which the… 
Highly Cited
2007
Highly Cited
2007
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… 
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Highly Cited
2005
Highly Cited
2005
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.
PURPOSE To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone… 
Highly Cited
2004
Highly Cited
2004
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress… 
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Highly Cited
2003
Highly Cited
2003
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat… 
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Highly Cited
2002
Highly Cited
2002
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and… 
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Highly Cited
2000
Highly Cited
2000
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in… 
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Highly Cited
1997
Highly Cited
1997
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins1. Modification of the cell… 
Highly Cited
1988
Highly Cited
1988
Hydroxamic acids (4-hydroxy-1,4-benzoxazin-3-ones), defence chemicals in the Gramineae
Abstract Hydroxamic acids of the type 4-hydroxy-1,4-benzoxazin-3-ones constitute one of the most extensively studied secondary… 
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Highly Cited
1961
Highly Cited
1961
A new and rapid colorimetric determination of acetylcholinesterase activity.
Abstract A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions… 
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