Hydroxamic Acids

Known as: Hydroxamic Acids [Chemical/Ingredient], Hydroxamic Acid, Acid, Hydroxamic 
A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities. Hydroxamic acids covalently… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression… (More)
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Highly Cited
2007
Highly Cited
2007
The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) were evaluated in… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To determine the safety, dosing schedules, pharmacokinetic profile, and biologic effect of orally administered histone… (More)
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Highly Cited
2003
Highly Cited
2003
Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused by a CAG/polyglutamine repeat… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE To evaluate the safety, pharmacokinetics, and biological activity of suberoylanilide hydroxamic acid (SAHA) administered… (More)
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Highly Cited
2002
Highly Cited
2002
Suberoylanilide hydroxamic acid (SAHA) is a hydroxamic acid-containing hybrid polar molecule; SAHA specifically binds to and… (More)
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Highly Cited
2001
Highly Cited
2001
Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate apoptosis. However, the upstream events leading… (More)
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Highly Cited
2000
Highly Cited
2000
Suberoylanilide hydroxamic acid (SAHA) is the prototype of a family of hybrid polar compounds that induce growth arrest in… (More)
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Highly Cited
1971
Highly Cited
1971
Hydroxamic acids, R-CONHOH, are inhibitors specific to the respiratory pathway through the alternate, cyanide-insensitive… (More)
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Highly Cited
1961
Highly Cited
1961
A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has… (More)
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