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Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
TLDR
These findings show that macrophages are defended from HIV-1 infection by a mechanism that prevents an unwanted interferon response triggered by self nucleic acids, and uncover an intricate relationship between innate immune mechanisms that control response to self and to retroviral pathogens.
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Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription
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Large-scale analysis of the yeast proteome by multidimensional protein identification technology
TLDR
MudPIT was applied to the proteome of the Saccharomyces cerevisiae strain BJ5460 grown to mid-log phase and yielded the largest proteome analysis to date, identifying 131 proteins with three or more predicted transmembrane domains which allowed us to map the soluble domains of many of the integral membrane proteins.
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Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae.
TLDR
An approach for analyzing shotgun proteomics datasets based on the normalized spectral abundance factor that can be used for quantitative proteomics analysis is devised and amino acid transporters were among the 14 membrane proteins that were significantly upregulated in cells grown in minimal media.
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Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions
TLDR
It is demonstrated that the Drosophila Tip60 (dTip60) chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av, revealing a previously unknown mechanism for selective histone exchange that uses the concerted action of two distinct Chromatin-Remodeling enzymes within the same multiprotein complex.
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A proteomic view of the Plasmodium falciparum life cycle
TLDR
A high-throughput proteomics approach was applied to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.
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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.
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The CRAPome: a Contaminant Repository for Affinity Purification Mass Spectrometry Data
TLDR
The contaminant repository for affinity purification (the CRAPome) is presented and its use for scoring protein-protein interactions is described and aggregating negative controls from multiple AP-MS studies can increase coverage and improve the characterization of background associated with a given experimental protocol.
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Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS
View on Elsevier
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