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Tumor Suppressor ARF, human

Known as: CDKN2A-p14ARF, p19(ARF), p14(ARF) 
Tumor suppressor ARF (173 aa, ~18 kDa) is encoded by the human CDKN2A gene. This protein is involved in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

23 relations
CDKN2A geneCDKN2A wt AlleleCTCF PathwayCell Cycle Control

Broader (2)

Cyclin-Dependent Kinase Inhibitor ProteinsCyclin-Dependent Kinase Inhibitor p16

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Regulation of the p14ARF promoter by DNA methylation
The INK4a/ARF locus encodes p14ARF which plays an important role in the p53 pathway. Interestingly, methylation of the INK4a/ARF… 
Highly Cited
2007
Highly Cited
2007
The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein
The alternative reading frame (ARF) mRNA encodes two pro-death proteins, the nucleolar p19ARF and a shorter mitochondrial isoform… 
2007
2007
Expression of the alternative reading frame protein of Hepatitis C virus induces cytokines involved in hepatic injuries.
Hepatitis C virus (HCV) Core has been implicated in immune-mediated mechanisms associated with the development of chronic hepatic… 
2005
2005
p14ARF Induces G2 Cell Cycle Arrest in p53- and p21-deficient Cells by Down-regulating p34cdc2 Kinase Activity*
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins, p16INK4a and p14ARF. Although primarily… 
Highly Cited
2003
Highly Cited
2003
Gene Fusion and Overlapping Reading Frames in the Mammalian Genes for 4E-BP3 and MASK*
4E-BP3 is a member of the eukaryotic initiation factor (eIF) 4F-binding protein family of translational repressors. eIF4E-binding… 
Highly Cited
2002
Highly Cited
2002
Human tumor suppressor ARF impedes S-phase progression independent of p53.
Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor… 
2002
2002
A Major Functional Difference between the Mouse and Human ARF Tumor Suppressor Proteins*
Suppression of tumorigenesis is considerably more stringent in the human than in the much shorter lived mouse species, and the… 
2001
2001
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
Oncogenic alterations can influence tumor cell survival partly by affecting the activity of the hypoxia-inducible factor-1 (HIF-1… 
2001
2001
c-Myc-mediated Regulation of Telomerase Activity Is Disabled in Immortalized Cells*
Myc overexpression is a hallmark of human cancer and promotes transformation by facilitating immortalization. This function has… 
Highly Cited
1992
Highly Cited
1992
Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of epsilon heavy chain membrane exons
We present evidence for RNA transcripts encoding two forms of human epsilon immunoglobulin (Ig) heavy chain that differ… 
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