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Tumor Suppressor ARF, human

Known as: CDKN2A-p14ARF, p19(ARF), p14(ARF) 
Tumor suppressor ARF (173 aa, ~18 kDa) is encoded by the human CDKN2A gene. This protein is involved in cell cycle arrest.
National Institutes of Health

Papers overview

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2008
2008
The INK4a/ARF locus encodes p14ARF which plays an important role in the p53 pathway. Interestingly, methylation of the INK4a/ARF… 
Highly Cited
2007
Highly Cited
2007
The alternative reading frame (ARF) mRNA encodes two pro-death proteins, the nucleolar p19ARF and a shorter mitochondrial isoform… 
2007
2007
Hepatitis C virus (HCV) Core has been implicated in immune-mediated mechanisms associated with the development of chronic hepatic… 
2005
2005
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins, p16INK4a and p14ARF. Although primarily… 
Highly Cited
2003
Highly Cited
2003
4E-BP3 is a member of the eukaryotic initiation factor (eIF) 4F-binding protein family of translational repressors. eIF4E-binding… 
Highly Cited
2002
Highly Cited
2002
Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor… 
2002
2002
Suppression of tumorigenesis is considerably more stringent in the human than in the much shorter lived mouse species, and the… 
2001
2001
Oncogenic alterations can influence tumor cell survival partly by affecting the activity of the hypoxia-inducible factor-1 (HIF-1… 
2001
2001
Myc overexpression is a hallmark of human cancer and promotes transformation by facilitating immortalization. This function has… 
Highly Cited
1992
Highly Cited
1992
We present evidence for RNA transcripts encoding two forms of human epsilon immunoglobulin (Ig) heavy chain that differ…