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Tumor Suppressor ARF, human

Known as: CDKN2A-p14ARF, p19(ARF), p14(ARF) 
Tumor suppressor ARF (173 aa, ~18 kDa) is encoded by the human CDKN2A gene. This protein is involved in cell cycle arrest.
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the… Expand
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Highly Cited
2003
Highly Cited
2003
The tumor suppressor ARF induces a p53-dependent and -independent cell cycle arrest. Unlike the nucleoplasmic MDM2 and p53, ARF… Expand
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Review
2000
Review
2000
  • C. Sherr
  • Cancer research
  • 2000
  • Corpus ID: 1016249
Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are present in most human cancers. Mitogen… Expand
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Highly Cited
1999
Highly Cited
1999
We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity for the tumor suppressor p53 protein… Expand
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Highly Cited
1998
Highly Cited
1998
The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the… Expand
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Highly Cited
1998
Highly Cited
1998
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading… Expand
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Highly Cited
1998
Highly Cited
1998
The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor… Expand
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Highly Cited
1997
Highly Cited
1997
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading… Expand
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Highly Cited
1997
Highly Cited
1997
Four INK4 proteins can prevent cell proliferation by specifically inhibiting cyclin D-dependent kinases. Both p18INK4c and… Expand
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Highly Cited
1995
Highly Cited
1995
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them… Expand
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