Tumor Suppressor ARF, human

Known as: CDKN2A-p14ARF, p19(ARF), p14(ARF) 
Tumor suppressor ARF (173 aa, ~18 kDa) is encoded by the human CDKN2A gene. This protein is involved in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

22 relations
CDKN2A geneCDKN2A wt AlleleCTCF PathwayCell Cycle Control
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Broader (2)

Cyclin-Dependent Kinase Inhibitor ProteinsCyclin-Dependent Kinase Inhibitor p16

Papers overview

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Highly Cited
2007
Highly Cited
2007
Delayed ageing through damage protection by the Arf/p53 pathway
The tumour-suppressor pathway formed by the alternative reading frame protein of the Cdkn2a locus (Arf) and by p53 (also called… (More)
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Highly Cited
2003
Highly Cited
2003
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.
The tumor suppressor ARF induces a p53-dependent and -independent cell cycle arrest. Unlike the nucleoplasmic MDM2 and p53, ARF… (More)
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Highly Cited
2000
Highly Cited
2000
p53-independent functions of the p19(ARF) tumor suppressor.
The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice… (More)
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Highly Cited
2000
Highly Cited
2000
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor.
Normal cells do not divide indefinitely due to a process known as replicative senescence. Human cells arrest growth with a… (More)
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Highly Cited
1999
Highly Cited
1999
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity for the tumor suppressor p53 protein… (More)
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Highly Cited
1998
Highly Cited
1998
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading… (More)
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Highly Cited
1998
Highly Cited
1998
E1A signaling to p53 involves the p19(ARF) tumor suppressor.
The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor… (More)
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Highly Cited
1998
Highly Cited
1998
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the… (More)
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Highly Cited
1997
Highly Cited
1997
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading… (More)
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Highly Cited
1995
Highly Cited
1995
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them… (More)
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