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Tumor Suppressor ARF, human

Known as: CDKN2A-p14ARF, p19(ARF), p14(ARF) 
Tumor suppressor ARF (173 aa, ~18 kDa) is encoded by the human CDKN2A gene. This protein is involved in cell cycle arrest.
National Institutes of Health

Related topics

Related topics

23 relations
CDKN2A geneCDKN2A wt AlleleCTCF PathwayCell Cycle Control
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Broader (2)

Cyclin-Dependent Kinase Inhibitor ProteinsCyclin-Dependent Kinase Inhibitor p16

Papers overview

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Highly Cited
2013
Highly Cited
2013
Somatic mutations of calreticulin in myeloproliferative neoplasms.
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the… Expand
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Highly Cited
2003
Highly Cited
2003
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.
The tumor suppressor ARF induces a p53-dependent and -independent cell cycle arrest. Unlike the nucleoplasmic MDM2 and p53, ARF… Expand
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Review
2000
Review
2000
The Pezcoller lecture: cancer cell cycles revisited.
  • C. Sherr
  • Cancer research
  • 2000
    • Corpus ID: 1016249
Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are present in most human cancers. Mitogen… Expand
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Highly Cited
1999
Highly Cited
1999
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity for the tumor suppressor p53 protein… Expand
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Highly Cited
1998
Highly Cited
1998
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the… Expand
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Highly Cited
1998
Highly Cited
1998
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading… Expand
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Highly Cited
1998
Highly Cited
1998
E1A signaling to p53 involves the p19(ARF) tumor suppressor.
The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor… Expand
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Highly Cited
1997
Highly Cited
1997
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading… Expand
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Highly Cited
1997
Highly Cited
1997
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
Four INK4 proteins can prevent cell proliferation by specifically inhibiting cyclin D-dependent kinases. Both p18INK4c and… Expand
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Highly Cited
1995
Highly Cited
1995
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them… Expand
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