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Upstream and downstream of mTOR.
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in… Expand
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We… Expand
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
- W. Filipowicz, S. Bhattacharyya, N. Sonenberg
- Biology, Medicine
- Nature Reviews Genetics
- 1 February 2008
MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding RNAs that have emerged as key post-transcriptional regulators of gene expression in metazoans and plants. In… Expand
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under most circumstances… Expand
Regulation of mRNA translation and stability by microRNAs.
MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base-pairing to the mRNA… Expand
Translational control in stress and apoptosis
Cells respond to stress stimuli through coordinated changes in gene expression. The regulation of translation is often used under these circumstances because it allows immediate and selective changes… Expand
Regulation of translation initiation by FRAP/mTOR.
RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation*
- Philippe P Roux, D. Shahbazian, +5 authors J. Blenis
- Biology, Medicine
- Journal of Biological Chemistry
- 11 May 2007
Converging signals from the mammalian target of rapamycin (mTOR) and phosphoinositide 3-kinase (PI3K) pathways are well established to modulate translation initiation. Less is known regarding the… Expand
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
Poliovirus RNA is naturally uncapped, therefore its translation must proceed via a cap-independent mechanism. Translation initiation on poliovirus RNA occurs by binding of ribosomes to an internal… Expand
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation.
The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1. By gene expression profiling, we defined a set of genes whose… Expand