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p53 isoforms can regulate p53 transcriptional activity.
The recently discovered p53-related genes, p73 and p63, express multiple splice variants and N-terminally truncated forms initiated from an alternative promoter in intron 3. To date, no alternativeExpand
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p53 in health and disease
  • K. Vousden, D. Lane
  • Medicine, Biology
  • Nature Reviews Molecular Cell Biology
  • 1 April 2007
As a component of the response to acute stress, p53 has a well established role in protecting against cancer development. However, it is now becoming clear that p53 can have a much broader role andExpand
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Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity
The only reported role for the conjugation of the NEDD8 ubiquitin-like molecule is control of the activity of SCF ubiquitin ligase complexes. Here, we show that the Mdm2 RING finger E3 ubiquitinExpand
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p53, guardian of the genome
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p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
p63, p73 and p53 compose a family of transcription factors involved in cell response to stress and development. p53 is the most frequently mutated gene in cancer (50%) and loss of p53 activity isExpand
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Awakening guardian angels: drugging the p53 pathway
Currently, around 11 million people are living with a tumour that contains an inactivating mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours in which the p53Expand
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SUMO‐1 modification activates the transcriptional response of p53
The p53 tumour suppressor protein is regulated by ubiquitin‐mediated proteasomal degradation. In normal cells p53 is constitutively ubiquitylated by the Mdm2 ubiquitin ligase. When the p53 responseExpand
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Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator
Summary We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds,Expand
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Regulation of the specific DNA binding function of p53
The DNA binding activity of p53 is required for its tumor suppressor function; we show here that this activity is cryptic but can be activated by cellular factors acting on a C-terminal regulatoryExpand
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Two Pathways for Base Excision Repair in Mammalian Cells (*)
Abasic sites (apurinic/apyrimidinic, AP sites) are the most common DNA lesions generated by both spontaneous and induced base loss. In a previous study we have shown that circular plasmid moleculesExpand
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