Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.
The involvement of c-Ski in theHDAC complex indicates that the function of the HDAC complex is important for oncogenesis and that Ski is required for the transcriptional repression mediated by this complex.
Disruption of Telomere Maintenance by Depletion of the MRE11/RAD50/NBS1 Complex in Cells That Use Alternative Lengthening of Telomeres*
- Ze-Huai Zhong, Wei-Qin Jiang, Anthony J. Cesare, A. Neumann, R. Wadhwa, R. Reddel
- BiologyJournal of Biological Chemistry
- 5 October 2007
It is concluded that the MRN complex, and especially NBS1, is required for the ALT mechanism, as evidenced by decreased numbers of ALT-associated promyelocytic leukemia bodies and decreased telomere length.
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
It is reported that MKT-077 binds to an hsp70 family member, mortalin (mot-2), and abrogates its interactions with the tumor suppressor protein, p53, and induced release of wild-type p53 from cytoplasmically sequestered p53-Mot-2 complexes and rescued its transcriptional activation function.
The Ski Protein Family Is Required for MeCP2-mediated Transcriptional Repression*
The results suggest that the ski gene family is involved in methyl CpG-mediated transcriptional repression, which is essential for development in the mouse and plays an important role in inactivation of the X chromosome and genomic imprinting.
Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells
A homology-based structural model of transmembrane protease serine 2 (TMPRSS2), a cell surface receptor, required for entry of virus to the target host cell is used, finding that both Wi-A and Wi-N could bind and stably interact at the catalytic site of TMPR SS2.
Proteomic Identification of a Stress Protein, Mortalin/mthsp70/GRP75
Manipulations of mortalin level in dopaminergic neurons resulted in significant changes in sensitivity to PD phenotypes via pathways involving mitochondrial and proteasomal function as well as oxidative stress.
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.
It is reported that the Ski corepressor binds to Gli3 and recruits the histone deacetylase complex, which plays an important role in pattern formation in Glioblastoma.
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis
The study demonstrates that upregulation of mortalin contributes significantly to tumorigenesis, and thus is a good candidate target for cancer therapy.
Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells
It is suggested that besides cholinergic blockade, scopolamine-induced memory loss may be associated with oxidative stress and Ashwagandha i-Extract, and withanone may serve as potential preventive and therapeutic agents for neurodegenerative disorders and hence warrant further molecular analyses.
Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy
It is demonstrated that the mortalin–p53 interaction exists in cancer cells that are either physiologically stressed (frequently associated with p53 mutations) or treated with stress-inducing chemicals.