Cyclin-Dependent Kinase Inhibitor Proteins

Known as: CDKI Protein, Cyclin-Dependent Kinase Inhibitor Proteins [Chemical/Ingredient], Cyclin Dependent Kinase Inhibitor Proteins 
A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2018
020406019922018

Papers overview

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Highly Cited
2005
Highly Cited
2005
Mutations in the MEN1 gene are associated with the multiple endocrine neoplasia syndrome type 1 (MEN1), which is characterized by… (More)
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Highly Cited
2005
Highly Cited
2005
In animals, cyclin-dependent kinase inhibitors (CKIs) are important regulators of cell cycle progression. Recently, putative CKIs… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECT Ionizing radiation is the gold-standard adjuvant treatment for glioblastoma multiforme (GBM), the most aggressive primary… (More)
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Highly Cited
2003
Highly Cited
2003
Silymarin, a defined mixture of natural flavonoid, has recently been shown to have potent cancer chemopreventive efficacy against… (More)
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Highly Cited
2001
Highly Cited
2001
After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant activation of the cell cycle machinery is… (More)
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Highly Cited
1999
Highly Cited
1999
The irreversible G1 arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G1 cyclin-cyclin… (More)
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Highly Cited
1999
Highly Cited
1999
Molecular mechanisms coupling growth arrest and cell differentiation were examined during adipogenesis. Data are presented that… (More)
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1998
1998
The cyclin dependent kinase holoenzymes (CDKs), composed of catalytic (cdk) and regulatory (cyclin) subunits, promote cellular… (More)
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Highly Cited
1996
Highly Cited
1996
Understanding how cyclin-cdk complexes recognize their substrates is a central problem in cell cycle biology. We identified an… (More)
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Highly Cited
1996
Highly Cited
1996
Alterations of various components of the cell cycle regulatory machinery that controls the progression of cells from a quiescent… (More)
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