Cyclin-Dependent Kinase Inhibitor p16

Known as: Cdk4-Associated Protein p16, p16INK4A Protein, Cyclin-Dependent Kinase Inhibitor-2A 
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli… (More)
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Highly Cited
2006
Highly Cited
2006
Increased mitogenic signaling by positive effectors such as Ras or Myc can trigger senescence in normal cells, a response… (More)
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Highly Cited
2003
Highly Cited
2003
Recent analyses of head and neck squamous cell carcinomas revealed frequent infections by oncogenic human papillomavirus (HPV… (More)
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Highly Cited
2000
Highly Cited
2000
Deregulation of cell cycle checkpoints is an almost universal abnormality in human cancers and is most often due to loss-of… (More)
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Highly Cited
2000
Highly Cited
2000
A role for the transcription factor JunB in proliferation control was investigated in genetically modified mouse fibroblasts… (More)
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1999
1999
The INK4A gene maps to the 9p21 region and was initially described [M. Serrano et al., Nature (Lond.), 366: 704-707, 1993; A… (More)
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Highly Cited
1999
Highly Cited
1999
To investigate the mode of action of the p16(INK4a) tumor suppressor protein, we have established U2-OS cells in which the… (More)
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Highly Cited
1998
Highly Cited
1998
The p16 protein (p16) is a cyclin-dependent kinase (CDK) inhibitor that decelerates the cell cycle by inactivating the CDKs that… (More)
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Highly Cited
1998
Highly Cited
1998
Proliferation of human mammary epithelial cells (HMEC) is limited to a few passages in culture due to an arrest in G1 termed… (More)
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Highly Cited
1995
Highly Cited
1995
Sporadic and familial malignant melanoma susceptibility has been linked to defects in the chromosomal region 9p21. Recently, a… (More)
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