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Cyclin-Dependent Kinase Inhibitor p16

Known as: Cdk4-Associated Protein p16, p16INK4A Protein, Cyclin-Dependent Kinase Inhibitor-2A 
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN… 
National Institutes of Health

Related topics

Related topics

16 relations
CDKN2A geneCDKN2A wt AlleleCDKN2B geneCyclin-Dependent Kinase Inhibitor 2A, human

Broader (1)

Carrier Proteins

Narrower (2)

Tumor Suppressor ARF, humanp19(ARF) protein, mouse

Papers overview

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Highly Cited
2005
Highly Cited
2005
Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma
Stepwise progression of peripheral‐type lung adenocarcinoma was characterized morphologically and was related to prognosis… 
2005
2005
Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.
It is known that p16(INK4) tumor suppressor gene expression in colon cancer cells is repressed by methylation at the CpG island… 
2005
2005
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
2004
2004
Invasion of Normal Human Fibroblasts Induced by v-FosIs Independent of Proliferation, Immortalization, and theTumor Suppressors p16INK4a andp53
ABSTRACT Invasion is generally perceived to be a late event during the progression of human cancer, but to date there are no… 
Highly Cited
2000
Highly Cited
2000
Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia.
p16/p15 regulate the cell cycle pathway by inhibiting the cyclin Ds-CDK4/6 mediated phosphorylation of pRb. We reported… 
Highly Cited
1999
Highly Cited
1999
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation
The p16 gene encoding a specific inhibitor of cyclin-dependent kinases 4 and 6 has been reported to be inactivated at a variety… 
1999
1999
Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease.
p16 protein binds and inactivates cyclin D-CDK4/6 complexes, stopping the cell cycle at the G1/S boundary. Loss of p16 expression… 
Highly Cited
1998
Highly Cited
1998
Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.
In this work, we address the question of whether replicative senescence can be induced in immortal nontumorigenic human… 
1998
1998
Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer.
The p16 tumor suppressor gene is thought to play an important role in cell cycle regulation by encoding for protein products that… 
1996
1996
p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.
The p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is frequently altered in cell lines and some… 
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