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Cyclin-Dependent Kinase Inhibitor p16

Known as: Cdk4-Associated Protein p16, p16INK4A Protein, Cyclin-Dependent Kinase Inhibitor-2A 
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN… 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Stepwise progression of peripheral‐type lung adenocarcinoma was characterized morphologically and was related to prognosis… 
2005
2005
It is known that p16(INK4) tumor suppressor gene expression in colon cancer cells is repressed by methylation at the CpG island… 
2004
2004
ABSTRACT Invasion is generally perceived to be a late event during the progression of human cancer, but to date there are no… 
Highly Cited
2000
Highly Cited
2000
p16/p15 regulate the cell cycle pathway by inhibiting the cyclin Ds-CDK4/6 mediated phosphorylation of pRb. We reported… 
Highly Cited
1999
Highly Cited
1999
The p16 gene encoding a specific inhibitor of cyclin-dependent kinases 4 and 6 has been reported to be inactivated at a variety… 
1999
1999
p16 protein binds and inactivates cyclin D-CDK4/6 complexes, stopping the cell cycle at the G1/S boundary. Loss of p16 expression… 
Highly Cited
1998
Highly Cited
1998
In this work, we address the question of whether replicative senescence can be induced in immortal nontumorigenic human… 
1998
1998
The p16 tumor suppressor gene is thought to play an important role in cell cycle regulation by encoding for protein products that… 
1996
1996
The p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is frequently altered in cell lines and some…