Cyclin-Dependent Kinase Inhibitor p16

Known as: Cdk4-Associated Protein p16, p16INK4A Protein, Cyclin-Dependent Kinase Inhibitor-2A 
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN… (More)
National Institutes of Health

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15 relations
CDKN2A geneCDKN2A wt AlleleCDKN2B geneCyclin-Dependent Kinase Inhibitor 2A, human
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Broader (1)

Carrier Proteins

Narrower (1)

Tumor Suppressor ARF, human

Papers overview

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Highly Cited
2011
Highly Cited
2011
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.
Cellular senescence suppresses cancer by preventing the proliferation of cells that experience potentially oncogenic stimuli… (More)
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Highly Cited
2006
Highly Cited
2006
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).
Increased mitogenic signaling by positive effectors such as Ras or Myc can trigger senescence in normal cells, a response… (More)
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Highly Cited
2003
Highly Cited
2003
Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus.
Recent analyses of head and neck squamous cell carcinomas revealed frequent infections by oncogenic human papillomavirus (HPV… (More)
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Highly Cited
2000
Highly Cited
2000
BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway.
Deregulation of cell cycle checkpoints is an almost universal abnormality in human cancers and is most often due to loss-of… (More)
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Highly Cited
2000
Highly Cited
2000
JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression.
A role for the transcription factor JunB in proliferation control was investigated in genetically modified mouse fibroblasts… (More)
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1999
1999
Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer.
The INK4A gene maps to the 9p21 region and was initially described [M. Serrano et al., Nature (Lond.), 366: 704-707, 1993; A… (More)
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Highly Cited
1999
Highly Cited
1999
Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes.
To investigate the mode of action of the p16(INK4a) tumor suppressor protein, we have established U2-OS cells in which the… (More)
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Highly Cited
1998
Highly Cited
1998
Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions.
The p16 protein (p16) is a cyclin-dependent kinase (CDK) inhibitor that decelerates the cell cycle by inactivating the CDKs that… (More)
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Highly Cited
1998
Highly Cited
1998
Inactivation of p16 in human mammary epithelial cells by CpG island methylation.
Proliferation of human mammary epithelial cells (HMEC) is limited to a few passages in culture due to an arrest in G1 termed… (More)
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Highly Cited
1995
Highly Cited
1995
Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression.
Sporadic and familial malignant melanoma susceptibility has been linked to defects in the chromosomal region 9p21. Recently, a… (More)
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