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Cyclin-Dependent Kinase Inhibitor p16
Known as:
Cdk4-Associated Protein p16
, p16INK4A Protein
, Cyclin-Dependent Kinase Inhibitor-2A
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A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN…
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National Institutes of Health
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Related topics
Related topics
16 relations
CDKN2A gene
CDKN2A wt Allele
CDKN2B gene
Cyclin-Dependent Kinase Inhibitor 2A, human
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Broader (1)
Carrier Proteins
Narrower (2)
Tumor Suppressor ARF, human
p19(ARF) protein, mouse
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma
R. Tanaka
,
Daye Wang
,
+6 authors
M. Noguchi
Cancer
2005
Corpus ID: 8926077
Stepwise progression of peripheral‐type lung adenocarcinoma was characterized morphologically and was related to prognosis…
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2005
2005
Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.
B. Kim
,
Hirofumi Yamamoto
,
+12 authors
M. Monden
International Journal of Oncology
2005
Corpus ID: 22996983
It is known that p16(INK4) tumor suppressor gene expression in colon cancer cells is repressed by methylation at the CpG island…
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2005
2005
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Y. Murai
,
S. Hayashi
,
Hiroyuki Takahashi
,
K. Tsuneyama
,
Y. Takano
Pathology, Research and Practice
2005
Corpus ID: 23809793
2004
2004
Invasion of Normal Human Fibroblasts Induced by v-FosIs Independent of Proliferation, Immortalization, and theTumor Suppressors p16INK4a andp53
L. Scott
,
J. Vass
,
E. Parkinson
,
D. Gillespie
,
J. N. Winnie
,
B. Ozanne
Molecular and Cellular Biology
2004
Corpus ID: 11778363
ABSTRACT Invasion is generally perceived to be a late event during the progression of human cancer, but to date there are no…
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Highly Cited
2000
Highly Cited
2000
Universal inactivation of both p16 and p15 but not downstream components is an essential event in the pathogenesis of T-cell acute lymphoblastic leukemia.
M. Omura‐Minamisawa
,
M. Diccianni
,
+6 authors
A. Yu
Clinical Cancer Research
2000
Corpus ID: 24544285
p16/p15 regulate the cell cycle pathway by inhibiting the cyclin Ds-CDK4/6 mediated phosphorylation of pRb. We reported…
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Highly Cited
1999
Highly Cited
1999
p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation
Makoto Nakamura
,
K. Sugita
,
+11 authors
S. Nakazawa
Leukemia
1999
Corpus ID: 24088710
The p16 gene encoding a specific inhibitor of cyclin-dependent kinases 4 and 6 has been reported to be inactivated at a variety…
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1999
1999
Loss of p16 protein expression associated with methylation of the p16INK4A gene is a frequent finding in Hodgkin's disease.
J. García
,
R. Villuendas
,
+5 authors
M. Piris
Laboratory investigation; a journal of technical…
1999
Corpus ID: 6657030
p16 protein binds and inactivates cyclin D-CDK4/6 complexes, stopping the cell cycle at the G1/S boundary. Loss of p16 expression…
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Highly Cited
1998
Highly Cited
1998
Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.
M. Vogt
,
C. Haggblom
,
J. Yeargin
,
T. Christiansen-Weber
,
M. Haas
Cell growth & differentiation : the molecular…
1998
Corpus ID: 13290405
In this work, we address the question of whether replicative senescence can be induced in immortal nontumorigenic human…
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1998
1998
Aberrant p16INK4 expression related to clinical stage and prognosis in patients with pancreatic cancer.
Takuji Naka
,
Makoto Kobayashi
,
Keigo Ashida
,
Nobuhiko Toyota
,
Tetsuya Kaneko
,
N. Kaibara
International Journal of Oncology
1998
Corpus ID: 22620285
The p16 tumor suppressor gene is thought to play an important role in cell cycle regulation by encoding for protein products that…
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1996
1996
p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.
T. Hirama
,
C. Miller
,
S. Wilczynski
,
H. Koeffler
Modern Pathology
1996
Corpus ID: 33192234
The p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is frequently altered in cell lines and some…
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