Cyclin-Dependent Kinase Inhibitor 2A, human

Known as: Cell Cycle Negative Regulator Beta, CDKN2A-p16(INK4a), MTS1 
Cyclin-dependent kinase inhibitor 2A (156 aa, ~17 kDa) is encoded by the human CDKN2A gene. This protein is involved in the inhibition of both cell… (More)
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
In the last decade, optimized treatment for non-small cell lung cancer had lead to improved prognosis, but the overall survival… (More)
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Highly Cited
2012
Highly Cited
2012
Cancer is a disease driven by genetic variation and mutation. Exome sequencing can be utilized for discovering these variants and… (More)
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Review
2010
Review
2010
Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA… (More)
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Highly Cited
2004
Highly Cited
2004
By expressing two genes (hTERT and Cdk4), we have developed a method to reproducibly generate continuously replicating human… (More)
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Highly Cited
2001
Highly Cited
2001
After mild ischemic insults, many neurons undergo delayed neuronal death. Aberrant activation of the cell cycle machinery is… (More)
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Highly Cited
2001
Highly Cited
2001
Cytological screening for cervical cancer or its precursors using Papanicolaou's smear test (Pap test) has been highly efficient… (More)
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Highly Cited
2000
Highly Cited
2000
Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence… (More)
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Highly Cited
2000
Highly Cited
2000
Promoter hypermethylation is an important pathway for repression of gene transcription in cancer cells. We analyzed aberrant DNA… (More)
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Highly Cited
1998
Highly Cited
1998
The two distinct proteins encoded by the CDKN2A locus are specified by translating the common second exon in alternative reading… (More)
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Highly Cited
1996
Highly Cited
1996
We describe the construction and characterization of retroviral vectors and packaging plasmids that produce helper-free… (More)
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