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Cyclin-Dependent Kinase Inhibitor 2A, human

Known as: Cell Cycle Negative Regulator Beta, CDKN2A-p16(INK4a), MTS1 
Cyclin-dependent kinase inhibitor 2A (156 aa, ~17 kDa) is encoded by the human CDKN2A gene. This protein is involved in the inhibition of both cell… 
National Institutes of Health

Related topics

Related topics

19 relations
CDKN2A geneCDKN2A wt AlleleCTCF PathwayCell Cycle Control

Papers overview

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Highly Cited
2008
Highly Cited
2008
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.
Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor… 
Highly Cited
2004
Highly Cited
2004
Genetic Pathways to Glioblastoma
We conducted a population-based study on glioblastomas in the Canton of Zurich, Switzerland (population, 1.16 million) to… 
Highly Cited
2004
Highly Cited
2004
Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins
By expressing two genes (hTERT and Cdk4), we have developed a method to reproducibly generate continuously replicating human… 
Highly Cited
2002
Highly Cited
2002
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Highly Cited
2001
Highly Cited
2001
Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
Cytological screening for cervical cancer or its precursors using Papanicolaou's smear test (Pap test) has been highly efficient… 
Highly Cited
2001
Highly Cited
2001
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer… 
Highly Cited
2001
Highly Cited
2001
Adenocarcinoma Epigenetic Patterns in the Progression of Esophageal Updated Version
Esophageal adenocarcinoma (EAC) arises after normal squamous mucosa undergoes metaplasia to specialized columnar epithelium… 
Review
1999
Review
1999
The INK4A/ARF locus and its two gene products.
Highly Cited
1998
Highly Cited
1998
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis.
The p16(INK4a) (p16) tumor suppressor gene can be inactivated by promoter region hypermethylation in many tumor types including… 
Highly Cited
1996
Highly Cited
1996
The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses
We describe the construction and characterization of retroviral vectors and packaging plasmids that produce helper-free… 
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