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The first suggestion that physical exercise results in free radical-mediated damage to tissues appeared in 1978, and the past… Expand Microbial-type rhodopsins are found in archaea, prokaryotes, and eukaryotes. Some of them represent membrane ion transport… Expand Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge… Expand The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It… Expand SUMMARY The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth. It is… Expand The doxorubicin-selected lung cancer cell line H69AR is resistant to many chemotherapeutic agents. However, like most tumor… Expand Comparative molecular field analysis (CoMFA) is a promising new approach to structure/activity correlation. Its characteristic… Expand Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction… Expand In 1901 a physician, Archibald Garrod, observed a patient with black urine. He used this simple observation to demonstrate that a… Expand Resistance of tumor cells to multiple cytotoxic drugs is a major impediment to cancer chemotherapy. Multidrug resistance in human… Expand