Organic Cation Transporter

Known as: Organic Cation Transport Protein 
Organic Cation Transporter proteins carry positively charged chemical substances containing covalently bound carbon atoms through solubility barriers… (More)
National Institutes of Health

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Review
2018
Review
2018
Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective… (More)
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Highly Cited
2008
Highly Cited
2008
Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the… (More)
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Highly Cited
2005
Highly Cited
2005
Although metformin, a cationic agent for type II diabetes, shows its pharmacological effect in the liver, the drug is mainly… (More)
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Highly Cited
2004
Highly Cited
2004
Crohn disease is a chronic, inflammatory disease of the gastrointestinal tract. A locus of ∼250 kb at 5q31 (IBD5) was previously… (More)
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Highly Cited
2004
Highly Cited
2004
Metformin, an antihyperglycemic agent, is eliminated by tubular secretion in addition to glomerular filtration in the human… (More)
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Highly Cited
2003
Highly Cited
2003
Rheumatoid arthritis is a common inflammatory disease with complex genetic components. We investigated the genetic contribution… (More)
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Highly Cited
2003
Highly Cited
2003
The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the… (More)
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Highly Cited
1999
Highly Cited
1999
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as… (More)
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Highly Cited
1999
Highly Cited
1999
Carnitine deficiency, either primary or drug-induced, causes critical symptoms and is thought to involve alteration of active… (More)
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Highly Cited
1997
Highly Cited
1997
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and… (More)
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