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cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.
TLDR
Findings suggest that OCT2 is responsible for the transport of cationic drugs in the kidney, and that this transcript was not detected in the brain, heart, lung, liver, small intestine or spleen. Expand
Gene expression levels and immunolocalization of organic ion transporters in the human kidney.
TLDR
Results suggest that hOOAT1, hOAT3, and hOCT2 play predominant roles in the transport of organic ions across the basolateral membrane of human proximal tubules. Expand
Cellular and molecular aspects of drug transport in the kidney.
TLDR
Detailed information concerning molecular and cellular aspects of drug transporters expressed in the kidney has facilitated studies of the mechanisms underlying renal disposition as well as transporter-mediated drug interactions. Expand
Cloning and Functional Characterization of a Novel Rat Organic Anion Transporter Mediating Basolateral Uptake of Methotrexate in the Kidney*
TLDR
The findings suggest that the rat OAT-K1 is localized in the basolateral membranes of renal tubules, where it mediates renal clearance of methotrexate from the blood. Expand
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
TLDR
The results suggested that both OCT1 and OCT2 are basolateral-type organic cation transporters with broad substrate specificities, mediating tubular secretion of cationic drugs. Expand
Prevalence and Factors Associated with Tinnitus: A Community-Based Study of Japanese Elders
TLDR
Findings suggest that tinnitus is common in Japanese aged over 65 years, and the factors associated with tinnitis in this cross-sectional study are potentially modifiable and should be thoroughly investigated in a longitudinal study. Expand
Gender difference in the relationships between vision and hearing impairments and negative well-being.
TLDR
Hearing impairment is significantly associated with negative well-being in older persons, and its association with depression may differ between males and females, while dual sensory impairment was associated with subjective poor health and reduced functional activity in both sexes. Expand
C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation.
TLDR
Genetic polymorphism of the MDR1 had some influence on the intestinal expression levels of Pgp and CYP3A4 and the tacrolimus concentration/dose ratio over the first postoperative days in recipients of living-donor liver transplantation (LDLT). Expand
Interaction of Imatinib Mesilate with Human P-Glycoprotein
TLDR
Observations demonstrate that imatinib mesilate is a substrate as well as a modulator of human P-gp, suggesting thatImatinib Mesilate drug interactions may occur via P- gp, and it is necessary to consider the pharmacokinetic and pharmacodynamic interactions of imatinIB mesilates with other drugs via P -gp. Expand
Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney.
TLDR
It is suggested that the rat PepT1 mediates H(+)-coupled uphill transport of the oral beta-lactam antibiotics across the brush-border membranes of intestinal and renal proximal tubular cells. Expand
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