E. Schömig

Publications139
h-index44
Citations8,024
Highly Influential Citations425
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Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
TLDR
The molecular identification and pharmacological characterization of the extraneuronal catecholamine transporter is reported, which is unrelated to the family of sodium-driven neuronal monoamine transporters.
Paraoxonase-1 is a major determinant of clopidogrel efficacy
TLDR
Using in vitro metabolomic profiling techniques, paraoxonase-1 (PON1) is identified as the crucial enzyme for clopidogrel bioactivation, with its common Q192R polymorphism determining the rate of active metabolite formation.
Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial.
TLDR
Data in this relatively small sample of otherwise healthy individuals with above-optimal BP indicate that inclusion of small amounts of polyphenol-rich dark chocolate as part of a usual diet efficiently reduced BP and improved formation of vasodilative nitric oxide.
Discovery of the ergothioneine transporter.
TLDR
The real-time PCR expression profile of human ETT, with strong expression in CD71+ cells, is consistent with a pivotal function ofET in erythrocytes, and prominent expression of ETT in monocytes and SLC22A4 polymorphism associations suggest a protective role of ET in chronic inflammatory disorders.
Selective substrates for non-neuronal monoamine transporters.
TLDR
Selective transport substrates were identified that allow, by analogy to receptor agonists, functional discrimination of these transporters and reveal key differences in solute recognition and turnover and thus challenge the concept of "polyspecific" organic cation transporter.
Effect of cocoa and tea intake on blood pressure: a meta-analysis.
TLDR
Current randomized dietary studies indicate that consumption of foods rich in cocoa may reduce blood pressure, while tea intake appears to have no effect.
Toxicokinetics of Acrylamide in Humans after Ingestion of a Defined Dose in a Test Meal to Improve Risk Assessment for Acrylamide Carcinogenicity
TLDR
Most of the acrylamide ingested with food is absorbed in humans, and the data suggests an at least 2-fold and 4-fold lower relative internal exposure for glycidamide from dietary acylamide in humans compared with rats or mice, respectively.
Absorption, Metabolization, and Antiplatelet Effects of 300-, 600-, and 900-mg Loading Doses of Clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose…
TLDR
Single doses of clopidogrel higher than 600 mg are not associated with an additional significant suppression of platelet function because of limited clopIDogrel absorption.
Transport of Monoamine Transmitters by the Organic Cation Transporter Type 2, OCT2*
TLDR
In situ hybridization reveals that, within the kidney, the OCT2r mRNA is restricted to the outer medulla and deep portions of the medullary rays indicating selective expression in the S3 segment of the proximal tubule, open the possibility that OCT2R plays a role in renal dopamine handling.
Impact of P‐glycoprotein on clopidogrel absorption
TLDR
The hypothesis that the intestinal efflux transporter P‐glycoprotein (P‐gp) limits the oral bioavailability of clopidogrel and that variance in the MDR1 gene encoding P‐gp predicts absorption variability is tested.
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