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Paraoxonase-1 is a major determinant of clopidogrel efficacy
Clinical efficacy of the antiplatelet drug clopidogrel is hampered by its variable biotransformation into the active metabolite. The variability in the clinical response to clopidogrel treatment hasExpand
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Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter
Catecholaminergic signaling regulates various physiological functions, such as blood pressure and is implicated in drug dependence, affective disorders and male aggressive behavior. The actions ofExpand
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Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial.
CONTEXT Regular intake of cocoa-containing foods is linked to lower cardiovascular mortality in observational studies. Short-term interventions of at most 2 weeks indicate that high doses of cocoaExpand
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Toxicokinetics of Acrylamide in Humans after Ingestion of a Defined Dose in a Test Meal to Improve Risk Assessment for Acrylamide Carcinogenicity
High amounts of acrylamide in some foods result in an estimated daily mean intake of 50 μg for a western style diet. Animal studies have shown the carcinogenicity of acrylamide upon oral exposure.Expand
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Effect of cocoa and tea intake on blood pressure: a meta-analysis.
BACKGROUND Epidemiological evidence suggests blood pressure-lowering effects of cocoa and tea. We undertook a meta-analysis of randomized controlled trials to determine changes in systolic andExpand
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Absorption, Metabolization, and Antiplatelet Effects of 300-, 600-, and 900-mg Loading Doses of Clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose
Background— For patients undergoing percutaneous coronary intervention, the administration of a clopidogrel loading dose ranging from 300 to 600 mg is currently recommended. It is unknown, though,Expand
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Selective substrates for non-neuronal monoamine transporters.
The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamineExpand
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Impact of P‐glycoprotein on clopidogrel absorption
The antiplatelet activity of clopidogrel is characterized by considerable interindividual differences. Variable intestinal absorption is suggested to contribute to the inconsistencies in response. WeExpand
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Transport of Monoamine Transmitters by the Organic Cation Transporter Type 2, OCT2*
The recently cloned apical renal transport system for organic cations (OCT2) exists in dopamine-rich tissues such as kidney and some brain areas (Gründemann, D., Babin-Ebell, J., Martel, F.,Expand
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Primary Structure and Functional Expression of the Apical Organic Cation Transporter from Kidney Epithelial LLC-PK1Cells*
Renal secretion of organic cations involves at least two distinct transporters, located in the basolateral and apical membranes of proximal tubule cells. Whereas the basolateral transporter hasExpand
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