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Models for the specific adhesion of cells to cells.
  • G. Bell
  • Chemistry, Medicine
  • Science
  • 12 May 1978
A theoretical framework is proposed for the analysis of adhesion between cells or of cells to surfaces when the adhesion is mediated by reversible bonds between specific molecules such as antigen andExpand
  • 3,226
  • 190
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in originExpand
  • 1,405
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritance, an onset usuallyExpand
  • 992
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Control of Pancreas and Liver Gene Expression by HNF Transcription Factors
The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combinedExpand
  • 1,216
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Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)
THE disease maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM), characterized by early onset,Expand
  • 908
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Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by abnormally high blood glucose resulting from a relative deficiency of insulin1. It affects about 2% of theExpand
  • 1,436
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Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Opioid drugs, such as morphine, and the endogenous opioid peptides, namely the enkephalins, endorphins, and dynorphins, exert a wide spectrum of physiological and behavioral effects, includingExpand
  • 583
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A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus
A polymorphic region flanking the human insulin gene on the short arm of chromosome 11, the insulin-gene-linked DNA polymorphism, can be described as a locus with at least three classes of alleles: aExpand
  • 747
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Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate.
Complex segregation analysis of pedigrees having nonsyndromic cleft lip with or without cleft palate (CL/P) (Chung et al. 1986; Marazita et al. 1986) has shown that a major-locus model best explainsExpand
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