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DNA Repair and Mutagenesis
TLDR
Nucleotide excision repair in mammalian cells: genes and proteins Mismatch repair The SOS response and recombinational repair in prokaryotes Mutagenesis in proKaryote Mutagenisation in eukaryotes Other DNA damage tolerance responses in eUKaryotes.
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.
  • G. Walker
  • Biology
    Microbiological reviews
  • 1 March 1984
TLDR
Comparing the SOS, Heat Shock, and Adaptive Regulatory Systems and evidence suggesting that UV mutagenesis does not require the induction of genes other than those repressed by LexA, the role of SOS processing to the spontaneous mutation frequency is suggested.
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
TLDR
The current state of knowledge about the eukaryotic DNA damage tolerance pathway translesion synthesis (TLS), a process in which specialized DNA polymerases replicate across from DNA lesions, is summarized.
Exopolysaccharide-deficient mutants of Rhizobium meliloti that form ineffective nodules.
TLDR
A firm and extensive correlation is established between the ability of Rhizobium to produce a particular polysaccharide and symbiotic proficiency and the exopolysaccharides involved in wild-type nodule invasion.
How rhizobial symbionts invade plants: the Sinorhizobium–Medicago model
TLDR
Recent discoveries about the mutual recognition process that allows the model rhizobial symbiont Sinorhizobium meliloti to invade and differentiate inside its host plant alfalfa and the model host plant barrel medic are reviewed.
RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and posttranslational activation.
TLDR
A series of genetic experiments are presented that indicate that the purpose of RecA-mediated cleavage of UmuD at its bond between Cys-24 and Gly-25 is to activate Umu D for its role in mutagenesis and that the COOH-terminal fragment of UmUD is necessary and sufficient for the role ofUmuD in UV Mutagenesis.
A LuxR Homolog Controls Production of Symbiotically Active Extracellular Polysaccharide II by Sinorhizobium meliloti
TLDR
The nature of the expR101 mutation in S. meliloti is determined, a spontaneous dominant mutation that results from precise, reading frame-restoring excision of an insertion sequence from the coding region of expR, a gene whose predicted protein product is highly homologous to the Rhizobium leguminosarum bv.
Antibiotics induce redox-related physiological alterations as part of their lethality.
TLDR
This work provides direct evidence that, downstream of their target-specific interactions, bactericidal antibiotics induce complex redox alterations that contribute to cellular damage and death, thus supporting an evolving, expanded model of antibiotic lethality.
Mechanisms of DNA damage, repair, and mutagenesis
TLDR
This introductory review will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue.
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