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Lipid oxidation is reduced in obese human skeletal muscle.
The data suggest that lesions at CPT-1 and post-CPT-1 events, such as mitochondrial content, contribute to the reduced reliance on fat oxidation evident in human skeletal muscle with obesity. Expand
Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice
Results show redundancy in the functions of PPars α and δ as transcriptional regulators of fatty acid homeostasis and suggest that in skeletal muscle high levels of the δ-subtype can compensate for deficiency of PPARα. Expand
Adiponectin is not altered with exercise training despite enhanced insulin action.
The data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity, and in contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adip onectin, which was accompanied by enhanced insulin action. Expand
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
It is concluded that impaired insulin-stimulated glucose uptake in skeletal muscle from severely obese subjects is accompanied by a deficiency in insulin receptor signaling, which may contribute to decreased insulin action. Expand
Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency*
It is proposed that PGC1α enables muscle mitochondria to better cope with a high lipid load, possibly reflecting a fundamental metabolic benefit of exercise training. Expand
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase.
AMP-activated protein kinase activation by AICAR increases GLut-4 transcription by a mechanism that requires response elements within 895 bp of human GLUT-4 proximal promoter and that may be cooperatively mediated by myocyte enhancer factor-2. Expand
Skeletal muscle lipid metabolism with obesity.
The data suggest that there is a defect in skeletal muscle fatty acid oxidation with extreme obesity but not overweight/obesity and that the accumulation of intramyocellular long-chain fatty acyl-CoAs is not solely a result of reduced fatty Acid oxidation. Expand
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.
It is concluded that GEF and MEF2 mediate the AMPK-induced increase in transcription of skeletal muscle GLUT4 and increase in binding to theGLUT4 promoter within 2 h after AICAR treatment. Expand
Muscle fiber type is associated with obesity and weight loss.
It is found that there is a relationship between muscle fiber type and obesity in lean and obese women and in obese individuals who lost weight after gastric bypass surgery. Expand
Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle.
  • P. Neufer, G. Dohm
  • Biology, Medicine
  • The American journal of physiology
  • 1 December 1993
It is proposed that the increase in GLut-4 mRNA evident with extended periods of training may result from a shift to pretranslational control and is the cumulative effect of repeated postexercise transient increases in GLUT-4 gene transcription. Expand