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Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis.
CONTEXT Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke. OBJECTIVE To assess the relationships of fibrinogen levels with risk of major vascularExpand
A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
It is shown that heparan sulfate modified by a subset of the multiple D-glucosaminyl 3-O-sulfotransferase isoforms provides sites for the binding of a third viral glycoprotein, gD, and for initiation of HSV-1 entry. Expand
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
The data indicate a dual role for adenosine triphosphate diphosphates in modulating hemostasis and thrombotic reactions and that cd39-deficient mice had prolonged bleeding times with minimally perturbed coagulation parameters. Expand
Multiple Isoforms of Heparan Sulfate d-Glucosaminyl 3-O-Sulfotransferase
The reiteration and conservation of the3-OST sulfotransferase domain suggest that this structure is a self-contained functional unit, and the extensive number of 3OST genes with diverse expression patterns of multiple transcripts suggests that the novel 3-OST enzymes, like 3-ost-1, regulate important biologic properties of heparan sulfate proteoglycans. Expand
Heparan sulfate proteoglycans of the cardiovascular system. Specific structures emerge but how is synthesis regulated?
The current state of knowledge about the structure and the biosynthesis of HSPGs are outlined as well as interactions of these components with growth factors, enzymes, and protease inhibitors are described to provide a conceptual framework for elucidating the roles of H SPGs in other biologic systems. Expand
PR39, a peptide regulator of angiogenesis
It is shown that a macrophage-derived peptide, PR39, inhibited the ubiquitin–proteasome-dependent degradation of hypoxia-inducible factor-1α protein, resulting in accelerated formation of vascular structures in vitro and increased myocardial vasculature in mice. Expand
Activation of coagulation after administration of tumor necrosis factor to normal subjects.
It is concluded that a single injection of tumor necrosis factor elicits a rapid and sustained activation of the common pathway of coagulation, probably induced through the extrinsic route and could play an important part in the earlyactivation of the hemostatic mechanism in septicemia. Expand
Vascular-bed--specific hemostasis and hypercoagulable states.
The extrinsic pathway of blood coagulation is initiated when blood is exposed to non-vascular-cell–bound tissue factor in the subendothelial space and activates factors IX and X of the intrinsic and common coagulated pathways, respectively. Expand
Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells.
It is demonstrated that exposure of bovine and human endothelial cells to TNF leads to suppression of the functional cell surface thrombin receptor, thrombomodulin (TM), and TM mRNA of virtually identical magnitude and that this inhibition does not require new protein synthesis. Expand
Molecular Cloning and Characterization of a Human Uronyl 2-Sulfotransferase That Sulfates Iduronyl and Glucuronyl Residues in Dermatan/Chondroitin Sulfate*
A partial-length human cDNA with a predicted amino acid sequence homologous to a previously described heparan sulfate iduronyl 2-sulfotransferase was obtained by searching the expressed sequence-tagged data bank and demonstrated ubiquitous expression of messages of 5.1 and 2.0 kilobases in a number of human tissues and in several human cancer cell lines. Expand