Neurosteroids: of the nervous system, by the nervous system, for the nervous system.
- E. Baulieu
- Biology, MedicineRecent Progress in Hormone Research
- 1997
A physiological function of neurosteroids in the central nervous system is strongly suggested by the role of hippocampal PREGS with respect to memory, observed in aging rats, and it may be important to study the effect of abnormal neurosteroid concentrations/metabolism with a view to the possible treatment of functional and trophic disturbances of the nervous system.
Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.
- E. Baulieu, G. Thomas, F. Forette
- MedicineProceedings of the National Academy of Sciences…
- 11 April 2000
A number of biological indices confirmed the lack of harmful consequences of this 50 mg/day DHEA administration over one year, indicating that this kind of replacement therapy normalized some effects of aging, but does not create "supermen/women" (doping).
Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.
- C. Corpéchot, P. Robel, M. Axelson, J. Sjövall, E. Baulieu
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 August 1981
It is proposed that Ia formation or accumulation in the rat brain depends on in situ mechanisms unrelated to the peripheral endocrine gland system.
Dehydroepiandrosterone (DHEA): a fountain of youth?
- E. Baulieu
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 September 1996
0 N SEPTEMBER 29 1675, the Marquise de Sevigne, then about 50, wrote in one her famous Letters; “. . . my health is the same as six years ago: I do not know where the Fountain of Youth (Fontaine de…
RU486 (mifepristone): mechanisms of action and clinical uses.
- F. Cadepond, A. Ulmann, E. Baulieu
- Medicine, BiologyAnnual Review of Medicine
- 1997
Clinically, the RU486-plus-prostaglandin method is close to being as convenient and safe as any medical method of abortion may be and the early use of RU486 as a contragestive as soon as a woman fears a pregnancy she does not want will help to defuse the abortion issue.
Neurosteroids: A new brain function?
- E. Baulieu, P. Robel
- Biology, ChemistryJournal of Steroid Biochemistry and Molecular…
- 20 November 1990
Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation
- E. Baulieu, C. Cho, D. Rose, M. Rosenfeld, R. Tsien, Zhiyong Wang
- Biology
- 2000
It is well known from positron-emission tomography (PET) data that rOEF maps in the normal human brain are largely flat despite considerable regional differences in rCBF and rCMRO2 maps.
Pregnenolone and its sulfate ester in the rat brain
- C. Corpéchot, M. Synguélakis, P. Robel
- Biology, ChemistryBrain Research
- 27 June 1983
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids.
- E. Baulieu, P. Robel
- Biology, MedicineProceedings of the National Academy of Sciences…
- 14 April 1998
This finding was unforeseen because the rodent steroidogenic glands, including the adrenals, do not secrete significant amounts of DHEA, and led to the discovery of a steroid biosynthetic machinery in the nervous system, in charge of producing neurosteroids.
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