Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein.
- D. Bikle, E. Gee, B. Halloran, M. A. Kowalski, E. Ryzen, J. Haddad
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 October 1986
It is concluded that 25OHD, like 1,25-dihydroxyvitamin D, is transported in blood bound primarily to DBP and albumin.
Effect of testosterone treatment on bone mineral density in men over 65 years of age.
- P. Snyder, H. Peachey, B. Strom
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 June 1999
Increasing the serum testosterone concentrations of normal men over 65 yr of age to the midnormal range for young men did not increase lumbar spine bone density overall, but did increase it in those men with low pretreatment serumosterone concentrations.
Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein.
- F. Safadi, P. Thornton, N. Cooke
- Biology, MedicineJournal of Clinical Investigation
- 15 January 1999
The role of DBP is to maintain stable serum stores of vitamin D metabolites and modulate the rates of its bioavailability, activation, and end-organ responsiveness, which may have evolved to stabilize and maintain serum levels of Vitamin D in environments with variable vitamin D availability.
Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels.
- D. Bikle, P. Siiteri, E. Ryzen, J. Haddad
- Biology, MedicineJournal of Clinical Endocrinology and Metabolism
- 1 November 1985
The results confirm the concept that although DBP is the principal protein carrier of 1,25-(OH)2D in serum, albumin is a major secondary carrier, especially in patients with low DBP levels.
Racial pigmentation and the cutaneous synthesis of vitamin D.
- L. Matsuoka, J. Wortsman, J. Haddad, P. Kolm, B. Hollis
- MedicineArchives of Dermatology
- 1 April 1991
It is concluded that while racial pigmentation has a photoprotective effect, it does not prevent the generation of normal levels of active vitamin D metabolites.
Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease.
- D. Bikle, E. Gee, B. Halloran, J. Haddad
- Medicine, BiologyJournal of Clinical Investigation
- 1 December 1984
The data suggest that free 1,25(OH)2D levels appear to be well maintained even in subjects with liver disease and reduced DBP levels, and free 1-25-dihydroxyvitamin D levels are increased during pregnancy despite the increase inDBP levels.
Human plasma transport of vitamin D after its endogenous synthesis.
- J. Haddad, L. Matsuoka, B. Hollis, Y. Hu, J. Wortsman
- Medicine, BiologyJournal of Clinical Investigation
- 1 June 1993
It is indicated that endogenously synthesized vitamin D3 travels in plasma almost exclusively on DBP, providing for a slower hepatic delivery of the vitamin D and the more sustained increase in plasma 25-hydroxycholecalciferol observed after depot, parenteral administration of vitamin D.
Angiopathic consequences of saturating the plasma scavenger system for actin.
- J. Haddad, K. D. Harper, M. Guoth, G. Pietra, J. Sanger
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 February 1990
It is suggested that in vivo saturation of these proteins' actin-binding capacities may serve as a paradigm for pulmonary vascular disorders seen during widespread tissue trauma and cell lysis.
Plasma vitamin D-binding protein (Gc-globulin): Multiple tasks
- J. Haddad
- BiologyJournal of Steroid Biochemistry and Molecular…
- 1 June 1995
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