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A Bayesian missing value estimation method for gene expression profile data
While the estimation performance of existing methods depends on model parameters whose determination is difficult, the BPCA method is free from this difficulty, and provides accurate and convenient estimation for missing values. Expand
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
Findings indicate that Rho regulates the CD44/ERM complex formation in vivo and that the phosphatidylinositol turnover may be involved in this regulation mechanism. Expand
Report of the 17th Nationwide Follow‐up Survey of Primary Liver Cancer in Japan †
  • I. Ikai, S. Arii, +9 authors M. Kudo
  • Medicine
  • Hepatology research : the official journal of the…
  • 1 September 2007
The cumulative survival rates of newly registered patients in the 12th to 17th follow‐up surveys conducted between 1992 and 2003 were calculated for each histological type (HCC, ICC, and combined HCC and ICC) and stratified by background factors and treatment. Expand
Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes*
The results showed that CLOCK and CRY proteins are involved in the transcriptional regulation of many circadian output genes in the mouse liver and appears to be involved in various physiological functions such as cell cycle, lipid metabolism, immune functions, and proteolysis in peripheral tissues. Expand
Implications of Nectin-like Molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in Cell-Cell Adhesion and Transmembrane Protein Localization in Epithelial Cells*
Results indicate the unique localization of Necl-2 and its possible involvement in localization of a transmembrane protein(s) through Pals2, a membrane-associated guanylate kinase family member known to bind Lin-7 implicated in the proper localization of the Let-23 protein in Caenorhabditis elegans. Expand
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.
The results suggest that p53DINP1 may regulate p53-dependent apoptosis through phosphorylation of p53 at Ser46, serving as a cofactor for the putative p 53-Ser46 kinase. Expand
High Incidence of Thrombosis of the Portal Venous System After Laparoscopic Splenectomy: A Prospective Study With Contrast-Enhanced CT Scan
PSVT is a more frequent complication of laparoscopic splenectomy than previously reported but can be treated safely following early detection by CT with contrast. Expand
Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma
It is suggested that, of the four receptors, EGF-R and c-erbB-3 play important roles in the progression of HCC and were not recognized as independent prognostic factors by multivariate analysis. Expand
Clinicopathologic Analysis of Breast Cancers with PIK3CA Mutations in Japanese Women
Purpose: Somatic mutations of PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase, have recently been shown to play an important role in the pathogenesis andExpand
A randomised phase III trial comparing gemcitabine with surgery-only in patients with resected pancreatic cancer: Japanese Study Group of Adjuvant Therapy for Pancreatic Cancer
It is suggested that adjuvant gemcitabine contributes to prolonged disease-free survival (DFS) in patients undergoing macroscopically curative resection of pancreatic cancer. Expand