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Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice
OBJECTIVE To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions of insulin sensitivity. RESEARCH DESIGN AND METHODS The number and the expressions ofExpand
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Abundant IgG4-Positive Plasma Cell Infiltration Characterizes Chronic Sclerosing Sialadenitis (Küttner's Tumor)
Chronic sclerosing sialadenitis (CSS) is a cryptogenic tumor-like condition of the salivary gland(s). While immune-mediated processes are suspected in its pathogenesis, and CSS is occasionallyExpand
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IgG4-related Sclerosing Cholangitis With and Without Hepatic Inflammatory Pseudotumor, and Sclerosing Pancreatitis-associated Sclerosing Cholangitis: Do They Belong to a Spectrum of Sclerosing
Sclerosing cholangitis (SC) is a heterogeneous disease entity. Different etiologies such as choledocholithiasis, biliary tumor, or pericholangitis can manifest as SC. Hepatic inflammatory pseudotumorExpand
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Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS
Septic shock is a severe systemic response to bacterial infection. Receptor for advanced glycation end products (RAGE) plays a role in immune reactions to recognize specific molecular patterns asExpand
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Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption1
The recruitment of osteoclast precursors toward osteoblasts and subsequent cell-cell interactions are critical for osteoclast differentiation. Chemokines are known to regulate cell migration andExpand
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RAGE Control of Diabetic Nephropathy in a Mouse Model
Diabetic nephropathy is a major microvascular complication in long-standing diabetic patients who eventually undergo renal dialysis or transplantation. To prevent development of this disease and toExpand
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Liver‐targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis
CD4+CD25high regulatory T cells (Tregs) play a critical role in self‐tolerance, as seen in murine autoimmunity. Studies on Tregs in human autoimmunity have focused primarily on peripheral bloodExpand
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Hepatic IL-17 responses in human and murine primary biliary cirrhosis.
The emergence of new regulatory and pro-inflammatory immune cell subsets and cytokines dictates the need to re-examine the role of these subsets in various diseases involving the immune system. IL-17Expand
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Radiofrequency ablation of small breast cancer followed by surgical resection
With the growing demand from patients for less‐invasive procedures, the shift from surgical extirpation to ablative local control of breast tumors is an emerging focus in breast cancer care. ThisExpand
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Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia.
Chronic inflammation is a common theme in a variety of disease pathways, including autoimmune diseases. The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitisExpand
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