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CDKN2A wt Allele

Known as: TP16, p14ARF, P16INK4 
Human CDKN2A wild-type allele is located in the vicinity of 9p21 and is approximately 27 kb in length. This allele, which encodes both cyclin… 
National Institutes of Health

Related topics

Related topics

24 relations
9p21Beckwith-Wiedemann SyndromeCDKN2B geneCTCF Pathway

Broader (1)

CDKN2A gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
The Negative Predictive Value of p16INK4a to Assess the Outcome of Cervical Intraepithelial Neoplasia 1 in the Uterine Cervix
Summary: The immunohistochemical expression of p16INK4a in formalin-fixed and paraffin-embedded histological sections was… 
Review
2005
Review
2005
New and unexpected: forkhead meets ARF.
Highly Cited
2005
Highly Cited
2005
Wild-type p53 overexpression and its correlation with MDM2 and p14ARF alterations: an alternative pathway to non-small-cell lung cancer.
PURPOSE We found a relatively reduced frequency of p53 mutation with a much greater frequency of p53 protein overexpression… 
Highly Cited
1999
Highly Cited
1999
Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer
Inactivation of the P16 (INK4A)/retinoblastoma (RB) or TP53 biochemical pathway is frequent event in most human cancers. Recent… 
Highly Cited
1997
Highly Cited
1997
Alterations of the p16 gene in head and neck cancer: frequency and association with p53, PRAD-1 and HPV
Alterations, especially homozygous deletions, of the putative tumor suppressor gene, p16 (p16INK4A, MTS1, CDKN2) have been found… 
Highly Cited
1996
Highly Cited
1996
Alterations of the p15, p16,and p18 genes in osteosarcoma.
Highly Cited
1995
Highly Cited
1995
CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple‐mole melanoma (FAMMM) syndrome families
Combined multi-point linkage analysis in seven Dutch families with FAMMM syndrome confirmed the location of a melanoma… 
Highly Cited
1995
Highly Cited
1995
Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds.
CDKN2 has been implicated as a melanoma susceptibility gene in some kindreds with a family history of this disease. Mutation… 
Highly Cited
1995
Highly Cited
1995
Homozygous loss of the p15INK4B gene (and not the p16INK4 gene) during tumor progression in a sporadic melanoma patient.
Homozygous deletions of 9p21, including the cyclin-dependent kinase inhibitor genes p16INK4 and p15INK4B, have been reported… 
Highly Cited
1994
Highly Cited
1994
Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.
The CDKN2 gene that encodes the cell cycle regulatory protein cyclin-dependent kinase-4 inhibitor (p16) has recently been mapped… 
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