CDKN2A wt Allele

Known as: TP16, p14ARF, P16INK4 
Human CDKN2A wild-type allele is located in the vicinity of 9p21 and is approximately 27 kb in length. This allele, which encodes both cyclin… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2017
0204019812017

Papers overview

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Highly Cited
2011
Highly Cited
2011
A 42 kb region on human chromosome 9p21 encodes for three distinct tumor suppressors, p16INK4A, p14ARF and p15INK4B, and is… (More)
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Highly Cited
2005
Highly Cited
2005
Bmi-1 is required for the post-natal maintenance of stem cells in multiple tissues including the central nervous system (CNS) and… (More)
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Highly Cited
2003
Highly Cited
2003
A central issue in stem cell biology is to understand the mechanisms that regulate the self-renewal of haematopoietic stem cells… (More)
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Highly Cited
2001
Highly Cited
2001
HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial… (More)
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Highly Cited
2000
Highly Cited
2000
Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence… (More)
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Highly Cited
1998
Highly Cited
1998
The INK4a gene encodes two distinct growth inhibitors--the cyclin-dependent kinase inhibitor p16Ink4a, which is a component of… (More)
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Highly Cited
1998
Highly Cited
1998
Normal human cells undergo a limited number of divisions in culture and enter a non-dividing state called replicative senescence… (More)
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Highly Cited
1997
Highly Cited
1997
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading… (More)
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Highly Cited
1996
Highly Cited
1996
The cell cycle inhibitor p16INK4a is inactivated in many human tumors and in families with hereditary melanoma and pancreatic… (More)
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Highly Cited
1994
Highly Cited
1994
TRANSFORMING growth factor-beta (TGF-β) inhibits cell proliferation by inducing a Gl-phase cell cycle arrest1. Normal progression… (More)
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