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CDKN2A wt Allele

Known as: TP16, p14ARF, P16INK4 
Human CDKN2A wild-type allele is located in the vicinity of 9p21 and is approximately 27 kb in length. This allele, which encodes both cyclin… 
National Institutes of Health

Related topics

Related topics

24 relations
9p21Beckwith-Wiedemann SyndromeCDKN2B geneCTCF Pathway

Broader (1)

CDKN2A gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
The diagnostic utility of p16 FISH and GLUT-1 immunohistochemical analysis in mesothelial proliferations.
Two promising ancillary tests used in the diagnosis of mesothelioma include GLUT-1 immunohistochemical analysis and fluorescence… 
Review
2005
Review
2005
New and unexpected: forkhead meets ARF.
Highly Cited
1999
Highly Cited
1999
Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer
Inactivation of the P16 (INK4A)/retinoblastoma (RB) or TP53 biochemical pathway is frequent event in most human cancers. Recent… 
Highly Cited
1999
Highly Cited
1999
Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms.
Tax oncoprotein of human T-cell leukemia virus type 1 (HTLV-1) affects multiple regulatory processes of infected cells through… 
Highly Cited
1996
Highly Cited
1996
Alterations of the p15, p16,and p18 genes in osteosarcoma.
Review
1996
Review
1996
Genetic aspects of uveal melanoma: a brief review.
Uveal melanoma usually occurs sporadically in the absence of obvious genetic predisposing factors. However, in rare patients… 
Highly Cited
1995
Highly Cited
1995
Increased p16 levels correlate with pRb alterations in human urothelial cells.
The CDKN2 (MTS1) gene is located at 9p21; its product, p16, inhibits the cyclin D/CDK4 complex that phosphorylates pRb, thus… 
Highly Cited
1995
Highly Cited
1995
Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene.
We have analyzed 12 microsatellite markers on chromosome 9p in 54 paired cutaneous malignant melanoma (CMM) tumors and normal… 
Highly Cited
1995
Highly Cited
1995
Analysis of the p16 gene, CDKN2, in 17 Australian melanoma kindreds.
CDKN2 has been implicated as a melanoma susceptibility gene in some kindreds with a family history of this disease. Mutation… 
Highly Cited
1994
Highly Cited
1994
Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.
The CDKN2 gene that encodes the cell cycle regulatory protein cyclin-dependent kinase-4 inhibitor (p16) has recently been mapped… 
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