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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
- M. Overholtzer, Jianmin Zhang, D. Haber
- BiologyProceedings of the National Academy of Sciences
- 15 August 2006
Observations point to a potential oncogenic role for YAP in 11q22-amplified human cancers, and suggest that this highly conserved signaling pathway identified in Drosophila regulates both cellular proliferation and apoptosis in mammalian epithelial cells.
BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.
- M. P. Deyoung, P. Horák, Avihu Sofer, D. Sgroi, L. Ellisen
- BiologyGenes & development
- 15 January 2008
It is demonstrated that hypoxia and REDD1 suppress mammalian TORC1 (mTORC1) activity by releasing TSC2 from its growth factor-induced association with inhibitory 14-3-3 proteins, which defines a molecular mechanism of signal integration by TSC1/2 that provides insight into the ability of REDD 1 to function in a hypoxIA-dependent tumor suppressor pathway.
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
Gene expression profiles of human breast cancer progression
- Xiao-Jun Ma, R. Salunga, D. Sgroi
- BiologyProceedings of the National Academy of Sciences…
- 24 April 2003
The combined use of laser capture microdissection and DNA microarrays generate in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer, revealing extensive similarities at the transcriptome level among the distinct stages of progression.
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials.
- D. Bell, T. Lynch, D. Haber
- Biology, MedicineJournal of clinical oncology : official journal…
- 1 November 2005
EGFR mutations and, to a lesser extent, amplification appear to identify distinct subsets of NSCLC with an increased response to gefitinib, and the combination of gefithinib with chemotherapy does not improve survival in patients with these molecular markers.
Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.
- D. Silver, A. Richardson, J. Garber
- Medicine, BiologyJournal of clinical oncology : official journal…
- 1 March 2010
A neoadjuvant trial of cisplatin in TNBC explored specific biomarkers to identify predictors of response and found decreased BRCA1 expression may identify subsets of TNBCs that are cis platin sensitive.