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CDKN2B gene

Known as: TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene 
This gene is involved in cell cycle regulation and arrest.
National Institutes of Health

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Related topics

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Beckwith-Wiedemann SyndromeCDKN2A geneCDKN2A wt AlleleCell Cycle Control

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CDKN2B wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
BackgroundThe INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. In this… 
2008
2008
Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids
Aims/hypothesisGenome-wide association studies (GWASs) recently identified common variants in the CDKN2A/CDKN2B region on… 
Highly Cited
2000
Highly Cited
2000
Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes
We previously reported that the hypermethylation of the p15INK4B gene promoter was frequently observed in myelodysplastic… 
1998
1998
Inactivations of p16INK4a-α, p16INK4a-β and p15INK4b genes in 2′, 3′-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas
The p16INK4a (α and β form) and p15INK4b genes were analysed for homozygous deletion, hypermethylation and point mutation in… 
Highly Cited
1997
Highly Cited
1997
Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma.
BACKGROUND Approximately 10% of human cutaneous melanomas occur in families in which several members are affected. The familial… 
1997
1997
Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.
The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4… 
Highly Cited
1996
Highly Cited
1996
Alterations of the p15, p16,and p18 genes in osteosarcoma.
1996
1996
Molecular analysis of the cyclin‐dependent kinase inhibitor genes p15INK4b/MTS21, p16INK4/MTS1, p18 and pl9 in human cancer cell lines
Cyclin‐dependent kinase‐4 inhibitor genes (INK4) regulate the cell cycle and are candidate tumor‐suppressor genes. To determine… 
Highly Cited
1995
Highly Cited
1995
Cloning and characterization of murine p16INK4a and p15INK4b genes.
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6… 
Highly Cited
1995
Highly Cited
1995
Homozygous loss of the p15INK4B gene (and not the p16INK4 gene) during tumor progression in a sporadic melanoma patient.
Homozygous deletions of 9p21, including the cyclin-dependent kinase inhibitor genes p16INK4 and p15INK4B, have been reported… 
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