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- Publications
- Influence
Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.
- T. Uchida, T. Kinoshita, +4 authors T. Murate
- Biology
- 15 August 1997
Previous studies have shown that the cyclin-dependent kinase inhibitor (CDKI) genes p15INK4B and p16INK4A are frequently inactivated by genetic alterations in many malignant tumors and that they are… Expand
Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice.
- M. Ichihara, T. Hara, H. Kim, T. Murate, A. Miyajima
- Biology, Medicine
- Blood
- 1 July 1997
Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are members of the interleukin-6 (IL-6) subfamily of cytokines that use a common signal transducer gp130. Human OSM (hOSM) and LIF share a… Expand
Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor‐induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12
- S. Sobue, K. Hagiwara, +7 authors T. Murate
- Biology, Medicine
- Journal of neurochemistry
- 1 November 2005
Sphingosine kinase (SPHK) is known to exert an anti‐apoptic role in various cells and cell lines. We previously reported that human brain is rich in SPHK1 ( Murate et al. 2001 ). After showing a high… Expand
Retrospective nationwide survey of Japanese patients with transfusion‐dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality
- M. Takatoku, T. Uchiyama, +8 authors K. Ozawa
- Medicine
- European journal of haematology
- 1 June 2007
Objective: Myelodysplastic syndromes (MDS) and aplastic anemia (AA) are the most common anemias that require transfusion therapy in Japan. This retrospective survey investigated relationships… Expand
Cell Type-specific Localization of Sphingosine Kinase 1a in Human Tissues
- T. Murate, Y. Banno, +11 authors Y. Nozawa
- Biology, Medicine
- The journal of histochemistry and cytochemistry…
- 1 July 2001
Cell type-specific localization of sphingosine kinase 1a (SPHK1a) in tissues was analyzed with a rabbit polyclonal antibody against the 16 C-terminal amino acids derived from the recently reported… Expand
HSNF5/INI1 gene mutations in lymphoid malignancy.
- M. Yuge, H. Nagai, +5 authors T. Kinoshita
- Biology, Medicine
- Cancer genetics and cytogenetics
- 1 October 2000
hSNF5/INI1 is one of the components of the SWI/SNF multiprotein complex that is necessary for the transcriptional activation of several genes and functions by altering chromatin structure. This gene… Expand
Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.
- T. Uchida, T. Kinoshita, +4 authors T. Murate
- Medicine
- Blood
- 1997
Previous studies have shown that the cyclin-dependent kinase inhibitor (CDKI) genes p15INK4B and p16INK4A are frequently inactivated by genetic alterations in many malignant tumors and that they are… Expand
High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation.
- Y. Akao, Y. Banno, +5 authors Y. Nozawa
- Biology, Medicine
- Biochemical and biophysical research…
- 21 April 2006
Although most of pharmacological therapies for cancer utilize the apoptotic machinery of the cells, the available anti-cancer drugs are limited due to the ability of prostate cancer cells to escape… Expand
The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin.
- T. Watanabe, T. Hotta, +5 authors H. Saito
- Biology, Medicine
- Blood
- 1 November 1994
The expression of the murine double minute-2 (MDM2) gene, the product of which binds to and inactivates p53, was studied in 60 patients with B-cell chronic lymphocytic leukemia (B-CLL) or… Expand
Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation*
- Satoshi Nemoto, M. Nakamura, +8 authors Y. Banno
- Biology, Medicine
- Journal of Biological Chemistry
- 17 April 2009
The relationship between sphingosine kinase (SPHK), cellular ceramide concentration and chemosensitivity was investigated in human colon cancer cell lines. Among nine colon cancer cell lines, SPHK1… Expand