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Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.
TLDR
Results suggest that hypermethylation of the p15INK4B gene is involved in the pathogenesis of M DS and is one of the important late events during the development of MDS.
Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice.
TLDR
Unlike hOSM, mOSM and mLIF do not share the same functional receptor, and mOSm delivers signals only through its specific receptor complex, which indicates that the physiological roles of OSM are still unknown.
Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor‐induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12
TLDR
The results suggest the signal transduction pathway from NGF receptor TrkA to transcription factor Sp1 protein binding to the promoter Sp1‐like motif in NGF‐induced rat SPHK1 gene expression is suggested.
Retrospective nationwide survey of Japanese patients with transfusion‐dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality
TLDR
This retrospective survey investigated relationships between iron overload, chelation practices, and morbidity/mortality in patients with these diseases.
Cell Type-specific Localization of Sphingosine Kinase 1a in Human Tissues
TLDR
Cell type-specific localization of sphingosine kinase 1a in tissues was analyzed with a rabbit polyclonal antibody against the 16 C-terminal amino acids derived from the recently reported mouse cDNA sequence of SPHK1a, suggesting that SPHK 1a may be a novel marker of megakaryocytic differentiation and that this antibody is also useful for in vitro study of differentiation models.
Exercise Training Alters Left Ventricular Geometry and Attenuates Heart Failure in Dahl Salt-Sensitive Hypertensive Rats
TLDR
Exercise training had a beneficial effect on cardiac remodeling and attenuated heart failure in hypertensive rats, with these effects likely being attributable to the attenuation of left ventricular concentricity and restoration of coronary angiogenesis through activation of phosphatidylinositol 3-kinase(p110&agr;)-Akt-mammalian target of rapamycin signaling.
Hypermethylation of the p15INK4B gene in myelodysplastic syndromes.
TLDR
Results suggest that hypermethylation of the p15INK4B gene is involved in the pathogenesis of M DS and is one of the important late events during the development of MDS.
HSNF5/INI1 gene mutations in lymphoid malignancy.
The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin.
TLDR
The results of the present study suggest that MDM2 gene overexpression may play an important role in the tumorigenicity and/or disease progression of CLL and low-grade lymphomas of B-cell origin.
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