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CDKN2A gene

Known as: p16 gene, TP16, p16INK4 Genes 
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies… 
National Institutes of Health

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Advanced Peritoneal Malignant MesotheliomaBeckwith-Wiedemann SyndromeBiphasic MesotheliomaCDKN2A Gene Mutation

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CDKN2A wt Allele

Papers overview

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Review
2001
Review
2001
Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas
ABSTRACT The frequent loss of both INK4a and ARF in melanoma raises the question of which INK4a-ARF gene product functions to… 
Highly Cited
2001
Highly Cited
2001
Invasive melanoma in Cdk4-targeted mice
Many human tumors harbor mutations that result in deregulation of Cdk4 activity. Most of these mutations involve overexpression… 
Highly Cited
1999
Highly Cited
1999
Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer
Inactivation of the P16 (INK4A)/retinoblastoma (RB) or TP53 biochemical pathway is frequent event in most human cancers. Recent… 
Highly Cited
1999
Highly Cited
1999
CDK4 gene amplification in osteosarcoma: Reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons
The INK4A gene, localized to human chromosome 9p21, encodes p16INK4A, a tumor suppressor that functions at least in part through… 
Highly Cited
1998
Highly Cited
1998
Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.
In this work, we address the question of whether replicative senescence can be induced in immortal nontumorigenic human… 
Highly Cited
1997
Highly Cited
1997
Induction of senescence in human malignant glioma cells by p16INK4A
p16INK4A is a G1-specific cell cycle inhibitor which maps to human chromosome 9p21, a region frequently mutated or deleted in… 
Highly Cited
1997
Highly Cited
1997
Frequent aberrant methylation of p16INK4a in primary rat lung tumors
The p16INK4a (p16) tumor suppressor gene is frequently inactivated by homozygous deletion or methylation of the 5' CpG island in… 
Review
1996
Review
1996
Compilation of somatic mutations of the CDKN2 gene in human cancers: Non‐random distribution of base substitutions
The CDKN2 gene, encoding the cyclin‐dependent kinase inhibitor p16, is a tumour suppressor gene that maps to chromosome band 9p21… 
Highly Cited
1995
Highly Cited
1995
Cloning and characterization of murine p16INK4a and p15INK4b genes.
Progression through the G1 phase of the cell cycle is regulated in part by the D-type cyclin-dependent kinases, cdk4 and cdk6… 
Highly Cited
1986
Highly Cited
1986
Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions.
Mouse L5178Y strain LY-S and its parental strain LY-R differ in their comparative sensitivities to the cytotoxic effects of… 
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