CDKN2A gene

Known as: p16 gene, TP16, p16INK4 Genes 
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number… (More)
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Highly Cited
2008
Highly Cited
2008
X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe… (More)
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Highly Cited
2007
Highly Cited
2007
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed… (More)
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Highly Cited
2007
Highly Cited
2007
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Germline mutations in the CDKN2A gene, which encodes two proteins (p16INK4A and p14ARF), are the most common cause of… (More)
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Highly Cited
2002
Highly Cited
2002
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related… (More)
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Review
2001
Review
2001
A plethora of physiological and pathological stimuli induce and activate a group of DNA binding proteins that form AP-1 dimers… (More)
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Highly Cited
1999
Highly Cited
1999
The bmi-1 gene was first isolated as an oncogene that cooperates with c-myc in the generation of mouse lymphomas,. We… (More)
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Highly Cited
1997
Highly Cited
1997
Oncogenic ras can transform most immortal rodent cells to a tumorigenic state. However, transformation of primary cells by ras… (More)
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Highly Cited
1995
Highly Cited
1995
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them… (More)
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