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CDKN2A gene

Known as: p16 gene, TP16, p16INK4 Genes 
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Objective Human gut microbiome studies are mainly bacteria- and archaea-oriented, overlooking the presence of single-cell… Expand
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Highly Cited
2011
Highly Cited
2011
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms… Expand
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Highly Cited
2005
Highly Cited
2005
Most normal mammalian cells have a finite lifespan, thought to constitute a protective mechanism against unlimited proliferation… Expand
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Highly Cited
2003
Highly Cited
2003
A central issue in stem cell biology is to understand the mechanisms that regulate the self-renewal of haematopoietic stem cells… Expand
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Review
2001
Review
2001
A plethora of physiological and pathological stimuli induce and activate a group of DNA binding proteins that form AP-1 dimers… Expand
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Highly Cited
1998
Highly Cited
1998
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor suppression. p16INK4 binds to and inhibits the… Expand
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Highly Cited
1998
Highly Cited
1998
The INK4a gene encodes two distinct growth inhibitors--the cyclin-dependent kinase inhibitor p16Ink4a, which is a component of… Expand
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Highly Cited
1997
Highly Cited
1997
Oncogenic ras can transform most immortal rodent cells to a tumorigenic state. However, transformation of primary cells by ras… Expand
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Highly Cited
1997
Highly Cited
1997
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading… Expand
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Highly Cited
1995
Highly Cited
1995
The INK4a (MTS1, CDKN2) gene encodes an inhibitor (p16INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them… Expand
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