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CDKN2A gene

Known as: p16 gene, TP16, p16INK4 Genes 
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies… 
National Institutes of Health

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Advanced Peritoneal Malignant MesotheliomaBeckwith-Wiedemann SyndromeBiphasic MesotheliomaCDKN2A Gene Mutation

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CDKN2A wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
X-linked SCID (SCID-X1) is amenable to correction by gene therapy using conventional gammaretroviral vectors. Here, we describe… 
Review
2005
Review
2005
INK4a/ARF: a multifunctional tumor suppressor locus.
Highly Cited
2002
Highly Cited
2002
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
Inactivation of tumour suppressor genes is central to the development of all common forms of human cancer. This inactivation… 
Highly Cited
2000
Highly Cited
2000
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.
The INK4a/ARF locus encodes two cell cycle-regulatory proteins, p16INK4a andp14ARF, which share an exon using different reading… 
Highly Cited
2000
Highly Cited
2000
CpG methylation is maintained in human cancer cells lacking DNMT1
Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the… 
Highly Cited
1999
Highly Cited
1999
Evolution of neoplastic cell lineages in Barrett oesophagus
It has been hypothesized that neoplastic progression develops as a consequence of an acquired genetic instability and the… 
Highly Cited
1996
Highly Cited
1996
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.
The recently identified cyclin-dependent kinase inhibitor p15INK4B is localized to a region on chromosome 9p21 frequently deleted… 
Highly Cited
1995
Highly Cited
1995
Complex structure and regulation of the P16 (MTS1) locus.
The p16 gene (P16, MTS1, CDKN2) encodes a negative regulator of the cell cycle. Molecular genetic techniques have been used to… 
Highly Cited
1994
Highly Cited
1994
Deletion of p16 and p15 genes in brain tumors.
We have used molecular genetic methods to examine the status of cell cycle-inhibitory genes in human brain tumors. We found that… 
Highly Cited
1992
Highly Cited
1992
Analysis of subtelomeric heterochromatin in the Drosophila minichromosome Dp1187 by single P element insertional mutagenesis.
We investigated whether single P element insertional mutagenesis could be used to analyze heterochromatin within the Drosophila… 
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