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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite…
In December 1997, the National Cancer Institute sponsored "The International Workshop on Microsatellite Instability and RER Phenotypes in Cancer Detection and Familial Predisposition," to review and… Expand
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
- M. Gillison, W. Koch, +9 authors D. Sidransky
- Journal of the National Cancer Institute
- 3 May 2000
BACKGROUND High-risk human papillomaviruses (HPVs) are etiologic agents for anogenital tract cancers and have been detected in head and neck squamous cell carcinomas (HNSCCs). We investigated,… Expand
p53 mutations in human cancers.
Mutations in the evolutionarily conserved codons of the p53 tumor suppressor gene are common in diverse types of human cancer. The p53 mutational spectrum differs among cancers of the colon, lung,… Expand
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common… Expand
Pathology & Genetics Head and Neck Tumours
Participation of p53 protein in the cellular response to DNA damage.
- M. Kastan, O. Onyekwere, D. Sidransky, B. Vogelstein, R. Craig
- Biology, Medicine
- Cancer research
- 1 December 1991
The inhibition of replicative DNA synthesis that follows DNA damage may be critical for avoiding genetic lesions that could contribute to cellular transformation. Exposure of ML-1 myeloblastic… Expand
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Background Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding antioxidants, xenobiotic… Expand
TP53 mutations and survival in squamous-cell carcinoma of the head and neck.
- M. L. Poeta, J. Manola, +10 authors W. Koch
- The New England journal of medicine
- 20 December 2007
BACKGROUND The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells. We evaluated TP53… Expand
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer.
- M. Xing, W. Westra, +19 authors P. Ladenson
- The Journal of clinical endocrinology and…
- 1 December 2005
CONTEXT Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve risk stratification of this cancer. OBJECTIVE The objective of the study was to investigate the… Expand
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
Germ-line mutations in the tumor suppressor gene APC are associated with hereditary familial adenomatous polyposis (FAP), and somatic mutations are common in sporadic colorectal tumors. We now report… Expand