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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite
TLDR
The spectrum of microsatellite alterations in noncolonic tumors was reviewed, and it was concluded that the above recommendations apply only to colorectal neoplasms.
Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
TLDR
It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
p53 mutations in human cancers.
TLDR
Transitions predominate in colorectal carcinomas, brain tumors, leukemias, and lymphomas, whereas G:C to T:A transversions are the most frequent substitutions observed in cancers of the lung and liver.
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
TLDR
To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
Participation of p53 protein in the cellular response to DNA damage.
TLDR
A role for the wild-type p53 protein in the inhibition of DNA synthesis that follows DNA damage is suggested and a new mechanism for how the loss of wild- type p53 might contribute to tumorigenesis is suggested.
Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
TLDR
This is the first study to the authors' knowledge to demonstrate that biallelic inactivation of KEAP1 is a frequent genetic alteration in NSCLC and suggests that tumor cells manipulate the NRF2 pathway for their survival against chemotherapeutic agents.
TP53 mutations and survival in squamous-cell carcinoma of the head and neck.
TLDR
Disruptive TP53 mutations in tumor DNA are associated with reduced survival after surgical treatment of squamous-cell carcinoma of the head and neck.
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer.
TLDR
In patients with PTC, BRAF mutation is associated with poorer clinicopathological outcomes and independently predicts recurrence, and may be a useful molecular marker to assist in risk stratification for patients withPTC.
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.
TLDR
It is reported that methylation in the promoter region of this gene constitutes an alternative mechanism for gene inactivation in colon and other tumors of the gastrointestinal tract and underscores the importance of the APC pathway in gastrointestinal tumorigenesis.
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