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Chk2 Mediates Stabilization of the FoxM1 Transcription Factor To Stimulate Expression of DNA Repair Genes
TLDR
A novel role for FoxM1 in the transcriptional response during DNA damage/checkpoint signaling is identified and a novel mechanism by which Chk2 protein regulates expression of DNA repair enzymes is shown. Expand
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor.
TLDR
It is demonstrated that conditional overexpression of Foxm1b protein in osteosarcoma U2OS cells greatly enhances anchorage-independent growth of cell colonies on soft agar and suggests that this (D-Arg)(9)-p19(ARF) 26-44 peptide is a potential therapeutic inhibitor of Fox m1b function during cellular transformation. Expand
FoxM1, a critical regulator of oxidative stress during oncogenesis
TLDR
FoxM1 is identified as a key regulator of ROS in dividing cells, and insights into the mechanism how tumour cells use FoxM1 to control oxidative stress to escape premature senescence and apoptosis are provided. Expand
The Xeroderma Pigmentosum Group E Gene Product DDB2 Is a Specific Target of Cullin 4A in Mammalian Cells
TLDR
It is shown that DDB2 is a cell cycle-regulated protein that is present at a low level in growth-arrested primary fibroblasts, and after release the level peaks at the G1/S boundary, suggesting that it is regulated by the ubiquitin-proteasome pathway. Expand
Cullin 4A Associates with the UV-damaged DNA-binding Protein DDB*
TLDR
Evidence that DDB or DDB-associated proteins are targets of cullin 4A (CUL-4A), a member of the cullin family of proteins, which are believed to be ubiquitin-protein isopeptide ligases (type E3), is provided. Expand
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
TLDR
The product of the RB gene is a part of E 2F-I and is involved in the regulation of E2F activity, and it is concluded that the retinoblastoma (RB) gene product copurifies with E2f-I activity. Expand
The Naturally Occurring Mutants of DDB Are Impaired in Stimulating Nuclear Import of the p125 Subunit and E2F1-Activated Transcription
TLDR
A new function is described of the p48 subunit of DDB, which reveals additional defects in the function of the XP-E mutants and suggests a possible link between the role of D DB in E2F1-activated transcription and the repair deficiency disease XP- E. Expand
FoxM1: a master regulator of tumor metastasis.
TLDR
Evidence for a master regulatory role of FoxM1 in tumor metastasis is discussed, which induces an epithelial-mesenchymal-like transition phenotype in HCC cells, increases cell migration, and induces premetastatic niche at the distal organ of metastasis. Expand
DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1
TLDR
It is shown that DDB, a putative DNA repair protein, associates with the activation domain of E2F1, and the results suggest that this damaged-DNA binding protein can function as a transcriptional partner of E 2F1. Expand
Tumor-prone phenotype of the DDB2-deficient mice
TLDR
The observations suggest that, in addition to DNA repair, the other interactions of DDB2 are significant in its tumor suppression function. Expand
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