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Mdm2 promotes the rapid degradation of p53
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations thatExpand
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The first 30 years of p53: growing ever more complex
Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen, the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 DNA and theExpand
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation andExpand
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The p53-Mdm2 module and the ubiquitin system.
The p53 tumor suppressor protein is a short-lived protein, which is stabilized in response to cellular stress. The ubiquitination and degradation of p53 are largely controlled by Mdm2, an oncogenicExpand
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Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATMExpand
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Mutant p53 gain-of-function in cancer.
  • M. Oren, V. Rotter
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 1 February 2010
In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53. Typically,Expand
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Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells
Histone modifications have emerged as important regulators of transcription. Histone H2B monoubiquitination has also been implicated in transcription; however, better understanding of the biologicalExpand
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Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network
We discovered that the mammalian miR regulatory network consists of several recurring motifs that recur in the network more than expected by chance. Expand
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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
Mutant p53 can contribute to transformation, while wild-type (wt) p53 is not oncogenic and actually inhibits transformation. Furthermore, wt p53 may act as a suppressor gene in human carcinogenesis.Expand
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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
WILD-TYPE p53 protein has many properties consistent with its being the product of a tumour suppressor gene1–3. Although the normal roles of tumour suppressor genes are still largely unknown, itExpand
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