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Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity
Peroxisomes have long been established to play a central role in regulating various metabolic activities in mammalian cells. These organelles act in concert with mitochondria to control theExpand
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Actin dynamics counteract membrane tension during clathrin-mediated endocytosis
Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence ofExpand
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The First Five Seconds in the Life of a Clathrin-Coated Pit
Coated pits assemble by growth of a clathrin lattice, which is linked by adaptors to the underlying membrane. How does this process start? We used live-cell TIRF imaging with single-molecule EGFPExpand
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Diverse intracellular pathogens activate Type III Interferon expression from peroxisomes
Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence ofExpand
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Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus.
In infected cells, hepatitis C virus (HCV) core protein is targeted to lipid droplets, which serve as intracellular storage organelles. Using a tissue culture system to generate infectious HCV, weExpand
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Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain. Perforin induces a transient Ca2+ flux in the target cell, which triggers aExpand
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Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication
ABSTRACT The mechanisms involved in hepatitis C virus (HCV) RNA replication are unknown, and this aspect of the virus life cycle is not understood. It is thought that virus-encoded nonstructuralExpand
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The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly*
Hepatitis C virus core protein forms the viral capsid and is targeted to lipid droplets (LDs) by its domain 2 (D2). By using a comparative analysis of two hepatitis C virus genomes (JFH1 and Jc1)Expand
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Structural Determinants That Target the Hepatitis C Virus Core Protein to Lipid Droplets*
Hepatitis C virus core protein is targeted to lipid droplets, which serve as intracellular storage organelles, by its C-terminal domain, termed D2. From circular dichroism and nuclear magneticExpand
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Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule‐ and Dynein‐Dependent Manner
Attachment of hepatitis C virus (HCV) core protein to lipid droplets (LDs) is linked to release of infectious progeny from infected cells. Core progressively coats the entire LD surface from a uniqueExpand
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