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Thromboxane (Tx) A2 is a vasoconstrictor and platelet agonist. Aspirin affords cardioprotection through inhibition of TxA2… Expand Virtually every organism has evolved mechanisms by which, upon stimulation, lipids are released from plasma membranes and… Expand Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 184.108.40.206) is present in cells under physiological… Expand BACKGROUND
Constriction of small pulmonary arteries and arterioles and focal vascular injury are features of pulmonary… Expand It has been suggested that platelet hyperreactivity in patients with diabetes mellitus is associated with increased platelet… Expand Pentoxifylline (oxpentifylline) is an orally active haemorheological agent for the treatment of peripheral vascular disease… Expand Preeclampsia is characterized by increased vasoconstriction frequently associated with increased platelet aggregation, reduced… Expand Acetylation of platelet cyclooxygenase by oral aspirin is dose dependent and cumulative with repeated administration. However, no… Expand Publisher Summary There is now a better understanding of the physiological role of prostaglandins. Major significance has been… Expand Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… Expand