Thromboxane A2

Known as: TXA-2, A2, Thromboxane, 9S,11S-Epoxy,15S-Hydroxy-Thromboxa-5Z,13E-Dien-1-Oic Acid 
An eicosanoid and short-lived intermediate product between prostaglandin endoperoxides and thromboxane B2, with prothrombotic and vasoconstrictive… (More)
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (9)

10,10-difluorothromboxane A215-hydroperoxythromboxane A2ONO 11113ONO 11120
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In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (2)

Rabbit Aorta Contracting SubstanceThromboxanes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology.
Thromboxane A(2) (TXA(2)), an unstable arachidonic acid metabolite, elicits diverse physiological/pathophysiological actions… (More)
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Review
2004
Review
2004
Cell signalling through thromboxane A2 receptors.
Thromboxane A2 receptors (TPs) are widely distributed among different organ systems and have been localized on both cell… (More)
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Highly Cited
2003
Highly Cited
2003
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity
Physical interaction of T cells and dendritic cells (DCs) is essential for T cell proliferation and differentiation, but it has… (More)
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Highly Cited
1999
Highly Cited
1999
Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis.
Cyclooxygenase-2 (COX-2) inhibitors reduce angiogenic responses to a variety of stimuli, suggesting that products of COX-2 may… (More)
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Highly Cited
1998
Highly Cited
1998
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.
Thromboxane A2 (TXA2) is a labile metabolite of arachidonic acid that has potent biological effects. Its actions are mediated by… (More)
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Highly Cited
1994
Highly Cited
1994
G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.
Using subtype-specific antisera, we were able to identify the recently described alpha subunits of G12 and G13 in platelet… (More)
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Highly Cited
1992
Highly Cited
1992
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension.
BACKGROUND Constriction of small pulmonary arteries and arterioles and focal vascular injury are features of pulmonary… (More)
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Highly Cited
1991
Highly Cited
1991
Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin.
BACKGROUND The antithrombotic efficacy of aspirin is attributed to its inhibition of the enzyme prostaglandin G/H synthase, which… (More)
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Review
1991
Review
1991
Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists.
Thromboxane (Tx) A2 is a product of cyclooxygenase catalyzed metabolism of arachidonic acid. It is formed via prostaglandin (PG… (More)
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Highly Cited
1976
Highly Cited
1976
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides
The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2… (More)
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