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Thromboxane A2

Known as: TXA-2, A2, Thromboxane, 9S,11S-Epoxy,15S-Hydroxy-Thromboxa-5Z,13E-Dien-1-Oic Acid 
An eicosanoid and short-lived intermediate product between prostaglandin endoperoxides and thromboxane B2, with prothrombotic and vasoconstrictive… Expand
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (9)

10,10-difluorothromboxane A215-hydroperoxythromboxane A2ONO 11113ONO 11120
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In BloodProcess of secretionThromboxane alpha 2:MCnc:Pt:Ser:Qnagonists
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Broader (2)

Rabbit Aorta Contracting SubstanceThromboxanes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2
Thromboxane (Tx) A2 is a vasoconstrictor and platelet agonist. Aspirin affords cardioprotection through inhibition of TxA2… Expand
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Highly Cited
1996
Highly Cited
1996
Periodontal Disease and Cardiovascular Disease.
It is our central hypothesis that periodontal diseases, which are chronic Gramnegative infections, represent a previously… Expand
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Highly Cited
1994
Highly Cited
1994
G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.
Using subtype-specific antisera, we were able to identify the recently described alpha subunits of G12 and G13 in platelet… Expand
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Highly Cited
1992
Highly Cited
1992
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension.
BACKGROUND Constriction of small pulmonary arteries and arterioles and focal vascular injury are features of pulmonary… Expand
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Highly Cited
1982
Highly Cited
1982
Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura.
A platelet-agglutinating factor has been detected in the plasma of some patients during episodes of thrombotic thrombocytopenic… Expand
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Highly Cited
1979
Highly Cited
1979
Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation
ASPIRIN prevents prostaglandin (PG) generation by directly inhibiting the cyclo-oxygenase enzyme responsible for PG biosynthesis1… Expand
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Highly Cited
1979
Highly Cited
1979
Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls.
PROSTAGLANDINS are potent vasoactive agents with a wide variety of other actions that depend on the species and organ tested and… Expand
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Review
1978
Review
1978
Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.
 
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Highly Cited
1976
Highly Cited
1976
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that… Expand
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Highly Cited
1975
Highly Cited
1975
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
An unstable [t1/2 at 37 degrees = 32 +/- 2 (SD) sec] intermediate, thromboxane A2, was detected in the conversion of… Expand
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