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Thromboxane A2
Known as:
TXA-2
, A2, Thromboxane
, 9S,11S-Epoxy,15S-Hydroxy-Thromboxa-5Z,13E-Dien-1-Oic Acid
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An eicosanoid and short-lived intermediate product between prostaglandin endoperoxides and thromboxane B2, with prothrombotic and vasoconstrictive…
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National Institutes of Health
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Related topics
Related topics
21 relations
Narrower (9)
10,10-difluorothromboxane A2
15-hydroperoxythromboxane A2
ONO 11113
ONO 11120
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In Blood
Process of secretion
Thromboxane alpha 2:MCnc:Pt:Ser:Qn
agonists
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Broader (2)
Rabbit Aorta Contracting Substance
Thromboxanes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases.
A. Simopoulos
Biomedicine & pharmacotherapy = Biomedecine…
2006
Corpus ID: 15875656
Highly Cited
2002
Highly Cited
2002
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2
Yan Cheng
,
S. Austin
,
+5 authors
G. FitzGerald
Science
2002
Corpus ID: 11900030
Thromboxane (Tx) A2 is a vasoconstrictor and platelet agonist. Aspirin affords cardioprotection through inhibition of TxA2…
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Highly Cited
2002
Highly Cited
2002
A role for uric acid in the progression of renal disease.
D. Kang
,
T. Nakagawa
,
+6 authors
Richard J. Johnson
Journal of the American Society of Nephrology…
2002
Corpus ID: 10647416
Hyperuricemia is associated with renal disease, but it is usually considered a marker of renal dysfunction rather than a risk…
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Highly Cited
1996
Highly Cited
1996
Periodontal Disease and Cardiovascular Disease.
J. Beck
,
R. Garcia
,
G. Heiss
,
P. Vokonas
,
S. Offenbacher
Journal of periodontology
1996
Corpus ID: 3928008
It is our central hypothesis that periodontal diseases, which are chronic Gramnegative infections, represent a previously…
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Highly Cited
1994
Highly Cited
1994
G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.
S. Offermanns
,
K. Laugwitz
,
K. Spicher
,
G. Schultz
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 20860496
Using subtype-specific antisera, we were able to identify the recently described alpha subunits of G12 and G13 in platelet…
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Highly Cited
1992
Highly Cited
1992
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension.
B. Christman
,
C. Mcpherson
,
+4 authors
J. Loyd
The New England journal of medicine
1992
Corpus ID: 31077387
BACKGROUND Constriction of small pulmonary arteries and arterioles and focal vascular injury are features of pulmonary…
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Highly Cited
1979
Highly Cited
1979
Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation
R. Flower
,
G. J. Blackwell
Nature
1979
Corpus ID: 4337393
ASPIRIN prevents prostaglandin (PG) generation by directly inhibiting the cyclo-oxygenase enzyme responsible for PG biosynthesis1…
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Highly Cited
1979
Highly Cited
1979
Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls.
S. Moncada
,
J. Vane
The New England journal of medicine
1979
Corpus ID: 10058985
PROSTAGLANDINS are potent vasoactive agents with a wide variety of other actions that depend on the species and organ tested and…
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Highly Cited
1976
Highly Cited
1976
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
S. Moncada
,
R. Gryglewski
,
S. Bunting
,
J. Vane
Nature
1976
Corpus ID: 4279030
Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that…
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Highly Cited
1975
Highly Cited
1975
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.
M. Hamberg
,
J. Svensson
,
B. Samuelsson
Proceedings of the National Academy of Sciences…
1975
Corpus ID: 22710071
An unstable [t1/2 at 37 degrees = 32 +/- 2 (SD) sec] intermediate, thromboxane A2, was detected in the conversion of…
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