• Publications
  • Influence
1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo*
TLDR
The potency and selectivity of 1400W inhibition of iNOS both in vitro and in vivo were far greater than of any previously described iN OS inhibitor.
Gastrointestinal effects of nonsteroidal anti‐inflammatory drugs
  • B. Whittle
  • Medicine, Biology
    Fundamental & clinical pharmacology
  • 1 June 2003
TLDR
TheCOX‐2 selective agents, the coxibs, which inhibit prostanoid biosynthesis at inflammatory sites, but not the endogenous protective prostanoids in the gut formed by COX‐1, have proved so far to be a successful therapeutic approach to reducing NSAIDs GI damage.
Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.
Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine,
The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa
TLDR
It is suggested that exogenous NO can protect the rat gastric mucosa from damage induced by the vasoconstrictor peptide ET‐1, which may reflect local microcirculatory interactions.
The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
TLDR
Findings suggest that induction of NOS is associated with the vascular injury induced by endotoxin in the rat colon and jejunum.
Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors.
  • B. Whittle
  • Medicine, Biology
    European journal of pharmacology
  • 1 October 2004
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