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1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo*
- E. Garvey, J. Oplinger, Richard Graham Knowles
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 February 1997
The potency and selectivity of 1400W inhibition of iNOS both in vitro and in vivo were far greater than of any previously described iN OS inhibitor.
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
Gastrointestinal effects of nonsteroidal anti‐inflammatory drugs
- B. Whittle
- Medicine, BiologyFundamental & clinical pharmacology
- 1 June 2003
TheCOX‐2 selective agents, the coxibs, which inhibit prostanoid biosynthesis at inflammatory sites, but not the endogenous protective prostanoids in the gut formed by COX‐1, have proved so far to be a successful therapeutic approach to reducing NSAIDs GI damage.
Synthesis of nitric oxide from L-arginine by neutrophils. Release and interaction with superoxide anion.
- T. Mccall, N. Boughton-Smith, R. Palmer, B. Whittle, S. Moncada
- Biology, MedicineThe Biochemical journal
- 1 July 1989
Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine,…
Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo.
The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa
- J. López-Belmonte, B. Whittle, S. Moncada
- Medicine, BiologyBritish journal of pharmacology
- 1 January 1993
It is suggested that exogenous NO can protect the rat gastric mucosa from damage induced by the vasoconstrictor peptide ET‐1, which may reflect local microcirculatory interactions.
The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
- N. Boughton-Smith, S. Evans, F. László, B. Whittle, S. Moncada
- Biology, MedicineBritish journal of pharmacology
- 1 November 1993
Findings suggest that induction of NOS is associated with the vascular injury induced by endotoxin in the rat colon and jejunum.
Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors.
- B. Whittle
- Medicine, BiologyEuropean journal of pharmacology
- 1 October 2004
Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.