P. Ramwell

Publications417
h-index52
Citations10,895
Highly Influential Citations93
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The vascular protective effects of estrogen
There is now strong epidemiological evidence that estrogen replacement therapy has a protective effect in postmenopausal women. The cardiovascular protective action of estrogen is reported to be… Expand
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17-Beta estradiol regulation of myocardial glutathione and its role in protection against myocardial stunning in dogs.
We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion.… Expand
  • 31
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L-arginine reverses the adverse pregnancy changes induced by nitric oxide synthase inhibition in the rat.
OBJECTIVE Inhibition of nitric oxide synthase with N omega-nitro-L-arginine methyl ester (L-NAME) induces a preeclampsia-like syndrome of hypertension, proteinuria, intrauterine growth restriction,… Expand
  • 103
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Cardiorespiratory, sympathetic and biochemical responses to T-2 toxin in the guinea pig and rat.
The cardiorespiratory, sympathetic and biochemical effects of T-2 toxin were examined in conscious rats and guinea pigs. The pithed rat preparation was also used to evaluate possible direct effects… Expand
  • 37
  • 3
Advances in prostaglandin and thromboxane research
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Spontaneous and evoked release of prostaglandins from frog spinal cord.
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Effect of prostaglandin E 2 and aspirin on the secondary aggregation of human platelets.
THE lack of cellular specificity1 of the prostaglandins creates potential hazards in their use as therapeutic agents: we describe one associated with PGE2 and the reversal of the effect with aspirin.
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Cellular mechanisms of prostaglandin action.
The human platelet and erythrocyte differ quite dramatically in relation to the arachidonic acid cascade. The platelet synthesizes its own characteristic products, while the erythrocyte lacks… Expand
  • 54
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The effect of prostaglandins E1 and E2 on the human erythrocyte as monitored by spin labels.
Abstract The effects of the prostaglandins PGE1 and PGE2 on the deformability of the human erythrocyte were studied using spin-labeled erythrocytes. Two magnetic resonance parameters were measured:… Expand
  • 109
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Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.
Furosemide is a potent vasodilator of the systemic arterial and venous systems. The mechanism of vasodilatation, however, remains unclear. We investigated the vasodilatory effect of furosemide and… Expand
  • 60
  • 2