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Nitric oxide: physiology, pathophysiology, and pharmacology.
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
NO released from endothelial cells is indistinguishable from EDRF in terms of biological activity, stability, and susceptibility to an inhibitor and to a potentiator. Expand
The L-arginine-nitric oxide pathway.
The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes. NitricExpand
Vascular endothelial cells synthesize nitric oxide from L-arginine
It is demonstrated that NO can be synthesized from L-arginine by porcine aortic endothelial cells in culture and the strict substrate specificity of this reaction suggests that L- arginine is the precursor for NO synthesis in vascular endothelium cells. Expand
Nitric oxide synthases in mammals.
This review will describe the known biochemical mechanisms involved in the synthesis of NO from L-arginine by the NO synthases and will also describe the nature of these enzymes, their inhibition and their molecular characteristics. Expand
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
In-vitro and in-vivo evidence that NO synthesis can be inhibited by an endogenous compound, NG,NG-dimethylarginine, ADMA is described, which might contribute to the hypertension and immune dysfunction associated with chronic renal failure. Expand
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
Results indicate that l‐NMMA, l‐NIO and l‐NAME are inhibitors of NO synthase in the vascular endothelium and confirm the important role of NO synthesis in the maintenance of vascular tone and blood pressure. Expand
Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide
The mitochondrial biogenesis induced by exposure to cold was markedly reduced in brown adipose tissue of endothelial nitric oxide synthase null-mutant (eNOS–/–) mice, which had a reduced metabolic rate and accelerated weight gain as compared to wild-type mice. Expand
Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS
Nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals. Expand