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Nitric oxide activates cyclooxygenase enzymes.
- D. Salvemini, T. P. Misko, J. Masferrer, K. Seibert, M. Currie, P. Needleman
- BiologyProceedings of the National Academy of Sciences…
- 1 August 1993
It is demonstrated that NO enhances COX activity through a mechanism independent of cGMP and suggested that, in conditions in which both the NOS and COX systems are present, there is an NO-mediated increase in the production of proinflammatory prostaglandins that may result in an exacerbated inflammatory response.
Arachidonic acid metabolism.
- P. Needleman, J. Turk, B. Jakschik, A. Morrison, J. Lefkowith
- Biology, MedicineAnnual review of biochemistry
C YC LOO XYGENASE PRODUC TS . . . LOOXYgenase PROD UC .
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.
The discovery and function of COX-2.
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides
- P. Needleman, S. Moncada, S. Bunting, J. Vane, M. Hamberg, B. Samuelsson
- Biology, MedicineNature
- 1 June 1976
The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting strips…
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.
- D. Salvemini, K. Seibert, J. Masferrer, T. P. Misko, M. Currie, P. Needleman
- BiologyThe Journal of clinical investigation
- 1 May 1994
The current study suggests that the endogenous release of NO from cNOS in the CLK activates a constitutive COX resulting in optimal PGE2 release by BK, and in the HNK, NO release from iNOS activates the induced COX causing markedly increased release of proinflammatory prostaglandin.
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.
We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide…
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria.
It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation.
Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties.
- P. Needleman, A. Raz, M. Minkes, J. Ferrendelli, H. Sprecher
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 February 1979
It is possible that the triene prostaglandins are potential antithrombotic agents because their precursor fatty acids, as well as their transformation products, PGH, thromboxane A(3), and PGI, are capable of interfering with aggregation of platelets in platelet-rich plasma.