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Nitric oxide activates cyclooxygenase enzymes.
TLDR
It is demonstrated that NO enhances COX activity through a mechanism independent of cGMP and suggested that, in conditions in which both the NOS and COX systems are present, there is an NO-mediated increase in the production of proinflammatory prostaglandins that may result in an exacerbated inflammatory response. Expand
Arachidonic acid metabolism.
TLDR
C YC LOO XYGENASE PRODUC TS . . . LOOXYgenase PROD UC . Expand
The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.
TLDR
Immunoprecipitation of [35S]methionine-labeled cyclooxygenase confirmed that the effect of lipopolysaccharide and dexamethasone on the monocyte prostanoid production could be attributed to an increase or decrease, respectively, in cellular cyclo oxygengenase de novo synthesis. Expand
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides
The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting stripsExpand
The discovery and function of COX-2.
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.
TLDR
The current study suggests that the endogenous release of NO from cNOS in the CLK activates a constitutive COX resulting in optimal PGE2 release by BK, and in the HNK, NO release from iNOS activates the induced COX causing markedly increased release of proinflammatory prostaglandin. Expand
Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria.
TLDR
It appears that atria possess at least two peptides that elicit smooth muscle relaxation and natriuresis, suggesting an endogenous system of fluid volume regulation. Expand
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).
TLDR
The putative glycosylation sites, transmembrane domain, and sequence similarities with functionally related enzymes have been incorporated into a model for the topology of cyclooxygenase in the endoplasmic reticulum. Expand
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.
We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxideExpand
Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.
TLDR
It appears that employing a dietary or a combined dietary/pharmacological paradigm to augment the cellular ratio of DGLA/AA is not an effective route to enhance endogenous synthesis of P GE(1) over PGE(2), at least in cells/tissues where COX-1 predominates over COX -2. Expand
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