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Top 100 relevant results, sorted by most influential
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
- P. Ridker, E. Danielson, +11 authors R. Glynn
- The New England journal of medicine
- 20 November 2008
BACKGROUND Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well… Expand
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.
Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major advances in treatment of coronary heart… Expand
Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.
- E. Garcia-Gras, R. Lombardi, +4 authors A. Marian
- Biology, Medicine
- The Journal of clinical investigation
- 3 July 2006
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is a genetic disease caused by mutations in desmosomal proteins. The phenotypic hallmark of ARVC is fibroadipocytic replacement of… Expand
Transendocardial, Autologous Bone Marrow Cell Transplantation for Severe, Chronic Ischemic Heart Failure
Background—This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote… Expand
Drs Ganz and Vita 1 and Verma, Buchanan, and Anderson2 have presented persuasive evidence that endothelial function is dynamically regulated and that the endothelium’s vasodilator, antiinflammatory,… Expand
Direct Proinflammatory Effect of C-Reactive Protein on Human Endothelial Cells
BackgroundThe acute-phase reactant C-reactive protein (CRP) is an important risk factor for coronary heart disease. However, the possible effects of CRP on vascular cells are not known. Methods and… Expand
Inflammation as a Cardiovascular Risk Factor
Inflammation occurs in the vasculature as a response to injury, lipid peroxidation, and perhaps infection. Various risk factors, including hypertension, diabetes, and smoking, are amplified by the… Expand
Leukocyte count and coronary heart disease: implications for risk assessment.
- M. Madjid, I. Awan, J. Willerson, S. Casscells
- Journal of the American College of Cardiology
- 16 November 2004
Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count is a marker of inflammation that is widely available in clinical practice. This paper reviews the… Expand
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.
- D. Guo, Christina L. Papke, +28 authors D. Milewicz
- Medicine, Biology
- American journal of human genetics
- 15 May 2009
The vascular smooth muscle cell (SMC)-specific isoform of alpha-actin (ACTA2) is a major component of the contractile apparatus in SMCs located throughout the arterial system. Heterozygous ACTA2… Expand
The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis.
BACKGROUND Recombinant human vascular endothelial growth factor protein (rhVEGF) stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials. VIVA (Vascular endothelial… Expand