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Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects.
Aspirin can achieve a ceiling effect on TXB2 production in healthy subjects at a considerably lower dosage than currently employed regimens for antithrombotic therapy. Expand
Anti-inflammatory effects of aspirin and sodium salicylate.
There is no common agreement about the extent to which salicylate contributes to aspirin's anti-inflammatory properties, as well as there is still no final conclusion reached about the mechanisms of action of sodium salicYLate. Expand
Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa.
It is concluded that increased formation of LTC4 and/or other 5-lipoxygenase-derived products of arachidonate metabolism may be involved in ethanol-induced gastric damage. Expand
Control of arachidonic acid accumulation in bone marrow-derived macrophages by acyltransferases.
- E. Kröner, B. Peskar, H. Fischer, E. Ferber
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 April 1981
The results suggest that in the cells studied, the level of free arachidonic acid is mainly controlled by the activity of the lysophosphatide acyltransferase. Expand
Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat.
- B. Peskar, K. Ehrlich, B. Peskar
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 June 2002
A role of K(ATP) channels in the gastroprotective effect of 16,16-dimethyl-PGE(2) and of the other agents tested is indicated, since the protection afforded by these agents is additionally indomethacin-sensitive. Expand
Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo.
The release of prostanoids from rat brain, gastric mucosa, lungs and kidneys incubated ex vivo and ketorolac tromethamine exhibited some organ selectivity with a particularly high activity in the kidneys suggesting that inhibition of central prostanoid biosynthesis could contribute to the rapid and effective inhibition of pain by both drugs. Expand
Evidence for a direct stimulatory effect of prostacyclin on renin release in man.
- C. Patrono, F. Pugliese, +7 authors A. Pierucci
- Chemistry, Medicine
- The Journal of clinical investigation
PGI(2) appears to act as a local modulator rather than a circulating hormone in controlling juxtaglomerular function and is not mediated by adrenergic stimuli or cyclooxygenase-dependent mechanisms secondary to hemodynamic changes. Expand
Afferent nerve-mediated protection against deep mucosal damage in the rat stomach.
Data indicate that afferent nerve stimulation by intragastric capsaicin protects against deep mucosal damage in response to ethanol, an effect that seems related to an increase in mucosal blood flow but not to eicosanoid formation. Expand
Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach
This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. Expand
Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis.
- T. Ruzicka, T. Simmet, B. Peskar, J. Ring
- The Journal of investigative dermatology
- 1 February 1986
The elevated levels of the potent proinflammatory and immunomodulating mediator LTB4 could be involved in the pathogenesis of cutaneous inflammation in atopic dermatitis and psoriasis and might explain the therapeutic efficiency of glucocorticosteroids. Expand