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Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors.
Data support the hypothesis that the EETs are EDHFs, which causes endothelium-dependent relaxations of coronary arteries through its metabolism to epoxyeicosatrienoic acids by cytochrome P450 by boosting the open-state probability of a Ca2+-activated K+ channel in coronary smooth muscle cells.
ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary. a report of the American college of cardiology/American heart association task force on…
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
- C. J. Hillard, S. Manna, W. Campbell
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 June 1999
ACPA and ACEA are high-affinity agonists of the CB1 receptor but do not bind the CB2 receptor, suggesting that structural analogs of AEA can be designed with considerable selectivity for theCB1 receptor over theCB2 receptor.
Epoxyeicosatrienoic acids and endothelium-dependent responses
The EETs are endothelium-derived hyperpolarizing factors mediating a portion of the relaxations to acetylcholine, bradykinin, shear stress, and cyclic stretch and regulate vascular tone in vitro and in vivo.
Accumulation of N‐Arachidonoylethanolamine (Anandamide) into Cerebellar Granule Cells Occurs via Facilitated Diffusion
The results suggest that AEA is accumulated by cerebellar granule cells by a protein‐mediated transport process that has the characteristics of facilitated diffusion.
The pharmacologic alteration of renin release.
Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism.
2-AG activation of CB(2) receptors may contribute to the proliferative response of microglial cells, as occurs in neurodegenerative disorders.
Characteristics and Superoxide-Induced Activation of Reconstituted Myocardial Mitochondrial ATP-Sensitive Potassium Channels
- David X. Zhang, Ya-Fei Chen, W. Campbell, A. Zou, G. Gross, Pin-Lan Li
- Biology, ChemistryCirculation research
- 1 December 2001
It is concluded that myocardial mitoKATP channels can be reconstituted into lipid bilayers and that O2−· activates these channels.
ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on…
New guidelines for the management of patients with supraventricular arrhythmias are introduced and recommended for use in combination with standard clinical practice.