• Publications
  • Influence
Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors.
TLDR
Data support the hypothesis that the EETs are EDHFs, which causes endothelium-dependent relaxations of coronary arteries through its metabolism to epoxyeicosatrienoic acids by cytochrome P450 by boosting the open-state probability of a Ca2+-activated K+ channel in coronary smooth muscle cells. Expand
ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary. a report of the American college of cardiology/American heart association task force on
TLDR
The ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the European Society of Cardiologist Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias). Expand
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
TLDR
ACPA and ACEA are high-affinity agonists of the CB1 receptor but do not bind the CB2 receptor, suggesting that structural analogs of AEA can be designed with considerable selectivity for theCB1 receptor over theCB2 receptor. Expand
Epoxyeicosatrienoic acids and endothelium-dependent responses
TLDR
The EETs are endothelium-derived hyperpolarizing factors mediating a portion of the relaxations to acetylcholine, bradykinin, shear stress, and cyclic stretch and regulate vascular tone in vitro and in vivo. Expand
Accumulation of N‐Arachidonoylethanolamine (Anandamide) into Cerebellar Granule Cells Occurs via Facilitated Diffusion
TLDR
The results suggest that AEA is accumulated by cerebellar granule cells by a protein‐mediated transport process that has the characteristics of facilitated diffusion. Expand
Epoxyeicosatrienoic acids activate K+ channels in coronary smooth muscle through a guanine nucleotide binding protein.
TLDR
It is concluded that 11,12-EET activates the KCa channels by a Gs alpha-mediated mechanism, which contributes to the effects of EETs as endothelium-derived hyperpolarizing factors tohyperpolarize and relax arterial smooth muscle. Expand
The pharmacologic alteration of renin release.
Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current.
TLDR
The findings suggest that the CB1 receptor and its endogenous ligand may play a fundamental role in the regulation of cerebral arterial tone and reactivity by modulating the influx of Ca2+ through L-type Ca2- channels. Expand
Characteristics and Superoxide-Induced Activation of Reconstituted Myocardial Mitochondrial ATP-Sensitive Potassium Channels
  • David X. Zhang, Ya-Fei Chen, W. Campbell, Ai-Ping Zou, Garrett J. Gross, Pin-Lan Li
  • Chemistry, Medicine
  • Circulation research
  • 1 December 2001
TLDR
It is concluded that myocardial mitoKATP channels can be reconstituted into lipid bilayers and that O2−· activates these channels. Expand
ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on
TLDR
New guidelines for the management of patients with supraventricular arrhythmias are introduced and recommended for use in combination with standard clinical practice. Expand
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